| Identification | Back Directory | [Name]
CGP77675 | [CAS]
234772-64-6 | [Synonyms]
CGP77675
CGP 77675; CGP-77675
CGP77675 >=98% (HPLC)
1-(4-(4-Amino-5-(3-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenethyl)piperidin-4-ol
1-(2-{4-[4-Amino-5-(3-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]phenyl}ethyl)piperidin-4-ol
4-Piperidinol, 1-[2-[4-[4-aMino-5-(3-Methoxyphenyl)-7H-pyrrolo[2,3-d]pyriMidin-7-yl]phenyl]ethyl]- | [Molecular Formula]
C26H29N5O2 | [MDL Number]
MFCD20039929 | [MOL File]
234772-64-6.mol | [Molecular Weight]
443.54 |
| Hazard Information | Back Directory | [Uses]
CGP77675 has been used in the generation of mouse expanded potential stem cells. | [General Description]
CGP77675 belongs to the pyrrolopyrimidine class of inhibitors. | [Biochem/physiol Actions]
CGP77675 is a potent Src kinase inhibitor. CGP77675 is selective toward other protein kinases including Cdc2 (>500-fold), epidermal growth factor (EGF) receptor (7.5-fold), vascular endothelial growth factor receptor (>50-fold), and for v-Abl (15-fold) and focal adhesion kinase (Fak) (>25-fold). | [in vivo]
CGP77675 (1, 5, and 25 mg/kg; injected s.c.; twice a day) inhibits IL-1β-induced hypercalcemia in Mice[1].
CGP77675 (10 and 50 mg/kg; administered orally; twice a day for 6 weeks) partially prevents bone loss and rescues bone microarchitectural features in young ovx rats[1]. | Animal Model: | Male mice (Tif:MAGf; Novartis Animal Farm) of 25-30 g body[1] | | Dosage: | 1, 5, and 25 mg/kg | | Administration: | Injected s.c.; twice a day | | Result: | Prevented IL-1β-induced hypercalcemia in mice without affecting serum amyloid protein levels. |
| Animal Model: | Eight-week-old (175-209 g) female rats of the Sprague-Dawley-derived strain Tif:RAlf[1] | | Dosage: | 10 and 50 mg/kg | | Administration: | Administered orally; twice a day for 6 weeks | | Result: | Partly prevented bone loss. |
| [storage]
Store at -20°C |
|
| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|