| Identification | Back Directory | [Name]
2-AMINO-5-FLUOROACETOPHENONE | [CAS]
2343-25-1 | [Synonyms]
1-(2-Amino-5-fluorophenyl)
2-AMINO-5-FLUOROACETOPHENONE
1-(2-AMino-5-fluorophenyl)ethanone
Ethanone, 1-(2-amino-5-fluorophenyl)-
1-(2-amino-5-fluorophenyl)ethan-1-one | [Molecular Formula]
C8H8FNO | [MDL Number]
MFCD09835333 | [MOL File]
2343-25-1.mol | [Molecular Weight]
153.155 |
| Chemical Properties | Back Directory | [Melting point ]
64-65 °C | [Boiling point ]
264.2±20.0 °C(Predicted) | [density ]
1.201±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [pka]
2.37±0.10(Predicted) |
| Hazard Information | Back Directory | [Synthesis]
600 g of 2-ethynyl-4-fluoroaniline and 4 L of water were added to the reaction flask, and then 476 g of hydrochloric acid (concentration: 35%) was added, and thereaction was carried out at 50 ??C for 36 hours.After the reaction, the temperature is lowered to 20-25 ??C, the reaction solution is adjusted to pH 8-9 with 50% sodium hydroxide solution, thetemperature is controlled to not exceed 30 ??C during pH adjustment, and the filter cake is washed with 1 L of water and decompressed at 50 ??C. After drying for 12 h, 622 g of pale yellow solid was obtained, yield91.4%.HPLC purity was 99.2%. |
|
|