| Chemical Properties | Back Directory | [Boiling point ]
870.8±65.0 °C(Predicted) | [density ]
0.956±0.06 g/cm3(Predicted) | [solubility ]
Soluble in Ethanol, DMSO, DMF | [form ]
Oil | [pka]
9.23±0.50(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
306Oi10 is a novel ionizable, biodegradable lipid for delivery of short interfering RNAs via lipid nanoparticles. | [Uses]
306Oi10 is a branched ionizable lipid that can be used to construct lipid nanoparticles (LNPs) for delivering messenger RNA. The surface ionization of lipid nanoparticles is related to the effectiveness of mRNA delivery. The tail of 306Oi10 has a one-carbon branch, which provides it with stronger surface ionization compared to lipids with linear tails, thereby enhancing its mRNA delivery efficacy. 306Oi10 can be used in research related to mRNA delivery[1][2]. | [in vivo]
304Oi10 (0.75 mg/kg, i,v., 15 min) effectively ionizes at pH 5.0 within C57BL/6 mice and demonstrates potent mRNA delivery efficacy[2]. | Animal Model: | C57BL/6 mice | | Dosage: | 0.75 mg/kg (LNPs carrying luciferase-encoding mRNA) | | Administration: | Intravenous injection (i.v.), 15 min | | Result: | Delivered luciferase in a dose-dependent manner in C57BL/6 mice, inducing luciferase expression predominantly in the liver (approximately 92%). |
| [References]
[1] Hajj K A. Lipid Nanoparticle Systems for the Delivery of Messenger RNA. Carnegie Mellon University, 2019.
[2] Hajj KA, et al. Branched-Tail Lipid Nanoparticles Potently Deliver mRNA In Vivo due to Enhanced Ionization at Endosomal pH. Small. 2019 Feb;15(6):e1805097. doi: 10.1002/smll.201805097. DOI:10.1002/smll.201805097 |
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| Company Name: |
DC Chemicals
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| Tel: |
021-8447131 13564518121 |
| Website: |
m.approvedhomemanagement.com/showsupplierproductslist927327/0.htm |
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