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ChemicalBook--->CAS DataBase List--->230615-23-3

230615-23-3

230615-23-3 Structure

230615-23-3 Structure
IdentificationBack Directory
[Name]

6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 6,7,8,9-tetrahydro-, monohydrochloride
[CAS]

230615-23-3
[Synonyms]

ChaMpix hydrochloride
Chantix hydrochloride
CP 526555 hydrochloride
Varenicline hydrochloride
CP 526555 HYDROCHLORIDE; CHAMPIX HYDROCHLORIDE; CHANTIX HYDROCHLORIDE
5,8,14-TRIAZATETRACYCLO[10.3.1.0(2,11).0(4,9)]HEXADECA-2(11),3,5,7,9-PENT+
7,8,9,10-tetrahydro-6H-6,10-methanoazepino[4,5-g]quinoxaline hydrochloride
6,7,8,9-Tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine hydrochloride
6,7,8,9-tetrahydro-6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine Monohydrochloride
6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 6,7,8,9-tetrahydro-, monohydrochloride
6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 7,8,9,10-tetrahydro-, hydrochloride (1:1)
6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 6,7,8,9-tetrahydro-,monohydrochloride (Varenicline Hcl)
6,7,8,9-Tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine hydrochloride (Varenicline hydrochloride)
[Molecular Formula]

C13H14ClN3
[MDL Number]

MFCD11042277
[MOL File]

230615-23-3.mol
[Molecular Weight]

247.73
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
[form ]

Powder
[color ]

Light yellow to khaki
Hazard InformationBack Directory
[Uses]

Varenicline Hydrochloride is a useful nicotine binding inhibitor.
[Biological Activity]

varenicline hydrochloride is a partial agonist of α4β2 nicotinic receptor for smoking cessation [1].varenicline hydrochloride has been reported to potently inhibit nachr binding with the ki values of 0.12±0.02 nm and 0.14±0.01 nm for α6β2* nachr and α4β2* nachr, respectively in rat striatum, 0.13±0.01 nm and 0.19±0.11 nm forα6β2* nachr and α4β2* nachr, respectively in monkey striatum. in addition, varenicline hydrochloride has shown to be more potent in stimulating both α6β2* and α4β2* nachrs compared with nicotine with the ec50 values of 0.007 and 0.086μm, respectively in rat striatum [1].
[storage]

Store at -20°C
[References]

[1] bordia t1, hrachova m, chin m, mcintosh jm, quik m. varenicline is a potent partial agonist at α6β2* nicotinic acetylcholine receptors in rat and monkey striatum. j pharmacol exp ther. 2012 aug;342(2):327-34. doi: 10.1124/jpet.112.194852. epub 2012 may 1.
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