| Identification | Back Directory | [Name]
5-Azidomethyl-2'-beta-methyl uridine | [CAS]
2305415-72-7 | [Synonyms]
5-Azidomethyl-2’-β-methyl uridine
5-Azidomethyl-2'-beta-methyl uridine | [Molecular Formula]
C11H15N5O6 | [MDL Number]
MFCD30718524 | [MOL File]
2305415-72-7.mol | [Molecular Weight]
313.27 |
| Hazard Information | Back Directory | [Uses]
5-Azidomethyl-2’-beta-methyl uridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. 5-Azidomethyl-2’-beta-methyl uridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [References]
[1] Cavanagh BL, et al. Thymidine analogues for tracking DNA synthesis. Molecules. 2011 Sep 15;16(9):7980-93. DOI:10.3390/molecules16097980
[2] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005 |
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