天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

ChemicalBook--->CAS DataBase List--->229305-39-9

229305-39-9

229305-39-9 Structure

229305-39-9 Structure
IdentificationBack Directory
[Name]

H-D-GLU(TRP-OH)-OH
[CAS]

229305-39-9
[Synonyms]

GLU-TRP
GolotiMod
GAMMA-GLU-TRP
Unii-637C487Y09
H-g-D-Glu-Trp-OH
H-GLU(TRP-OH)-OH
gamma-D-Glu-L-Trp
H-D-GLU(TRP-OH)-OH
H-GAMMA-GLU-TRP-OH
H-GAMMA-D-GLU-TRP-OH
gammaDglutamylLtryptophan
L-Tryptophan, D-γ-glutamyl-
GOLOTIMOD (UNII-637C487Y09)
H-g-D-Glu-Trp-OH, GolotiMod, BestiM
SCV 07; SCV-07; SCV07; GAMMADGLUTAMYLLTRYPTOPHAN
(2R)-2-amino-5-[[(1S)-1-carboxy-2-(1H-indol-3-yl)ethyl]amino]-5-oxopentanoic acid
[Molecular Formula]

C16H19N3O5
[MDL Number]

MFCD00057875
[MOL File]

229305-39-9.mol
[Molecular Weight]

333.34
Chemical PropertiesBack Directory
[Boiling point ]

737.3±60.0 °C(Predicted)
[density ]

1.428±0.06 g/cm3(Predicted)
[storage temp. ]

−20°C
[solubility ]

Soluble in DMSO
[form ]

Solid
[pka]

2.22±0.10(Predicted)
[color ]

White to off-white
Safety DataBack Directory
[WGK Germany ]

3
Hazard InformationBack Directory
[Uses]

Golotimod (SCV-07), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and splenic cell proliferation, and improves macrophage function. Golotimod (SCV-07) inhibits STAT3 signaling and modulates the duration and severity of oral mucositis in animal models that received radiation or a combination of radiation and Cisplatin. Golotimod (SCV-07) is also a potential therapeutic for recurrent genital herpes simplex virus type 2 (HSV-2)[1][2][3].
[Definition]

ChEBI:Golotimod is a dipeptide.
[in vivo]

Golotimod (SCV-07) (oral gavage or subcutaneous injection, 100 μg/kg, 5 days) reduces experimental recurrent genital HSV-2 disease by oral administration, more importantly, oral SCV07 after fasting shows a greater reduction in incidence and severity than SCV-07 without fasting in female hartley guinea pigs[1].
Golotimod (SCV-07) (subcutaneous injection, once or twice a day from days 1 to 20, 100 μg/kg) can reduce the severity and duration of acute and split radiation-induced oral mucositis (OM) and short the duration of ulcerative OM in male LVG golden Syrian Hamsters[3].

Animal Model:Female Hartley guinea pigs (250-300 g) infected HSV-2[1]
Dosage:100 μg/kg
Administration:Oral gavage or subcutaneous injection; 5 days
Result:Reduced incidence of lesions from 55% (one week before treatment) to only 18% by oral administration, and showed no significant reduction in disease by subcutaneous injection of SCV-07.
Animal Model:Male LVG golden Syrian Hamsters weighing approximately 80 g with radiation-induced mucositis[3]
Dosage:10, 100 μg/kg or 1 mg/kg
Administration:Subcutaneous injection; once or twice a day from days 1 to 20
Result:Showed a peak mucositis of 3.0 on day 18 in the control group compared to only 2.2 in the test group, and the mucositis score in the SCV-07 treated hamsters was only 6.3% compared to 28.1% in the control group at dose of 100 μg/kg.
Significantly decreased the severity and duration of oral mucositis (OM) at dose of 10 μg/kg, 100 μg/kg or 1 mg/kg.
[IC 50]

STAT3
[storage]

Store at -20°C
[References]

[1] Rose WA 2nd, et al. An immunomodulating dipeptide, SCV-07, is a potential therapeutic for recurrent genital herpes simplex virus type 2 (HSV-2). Int J Antimicrob Agents. 2008 Sep;32(3):262-6. DOI:10.1016/j.ijantimicag.2008.04.010
[2] Geiger JL, et al. The STAT3 pathway as a therapeutic target in head and neck cancer: Barriers and innovations. Oral Oncol. 2016 May;56:84-92. DOI:10.1016/j.oraloncology.2015.11.022
[3] Watkins B, et al. Attenuation of radiation- and chemoradiation-induced mucositis using gamma-D-glutamyl-L-tryptophan (SCV-07). Oral Dis. 2010 Oct;16(7):655-60. DOI:10.1111/j.1601-0825.2010.01671.x
229305-39-9 suppliers list
Company Name: Changzhou PBpharmaceutical R&D Co.,Ltd
Tel: 0519-83990708
Website: m.approvedhomemanagement.com/ShowSupplierProductsList31332/0.htm
Company Name: BOC Sciences
Tel: +1-631-485-4226
Website: www.bocsci.com/
Company Name: career henan chemical co
Tel: +86-0371-86658258 +8613203830695 , +8613203830695
Website: www.coreychem.com
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000 , +1-00000000000
Website: https://www.targetmol.com/
Company Name: Zhejiang J&C Biological Technology Co.,Limited
Tel: +1-2135480471 +1-2135480471 , +1-2135480471
Website: https://www.sarms4muscle.com
Company Name: Nextpeptide Inc
Tel: +86-0571-81612335 +8613336028439 , +8613336028439
Website: http://www.nextpeptide.com/
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105 , +1-13798911105
Website: https://www.invivochem.com/
Company Name: Hangzhou MolCore BioPharmatech Co.,Ltd.
Tel: +86-057181025280; +8617767106207 , +8617767106207
Website: https://www.molcore.com/
Company Name: Henan Aochuang Chemical Co.,Ltd.
Tel: +86-0371-63689365 +8618638391208 , +8618638391208
Website: http://www.aochuangchem.com/
Company Name: TargetMol Chemicals Inc.
Tel:
Website: www.targetmol.com/
Company Name: Hebei Miaoyin Technology Co.,Ltd
Tel: +86-17367732028 +86-17367732028 , +86-17367732028
Website: m.approvedhomemanagement.com/manufacturer/hebei-miaoyin-technology-25082/
Company Name: Nanjing TGpeptide
Tel: +86-13347807150 +86-13347807150 , +86-13347807150
Website: tgpeptides.com/index.aspx
Company Name: Changsha MOL Changes Biotechnology Co., Ltd.
Tel: +8619375158599 , +8619375158599
Website: www.molchanges.com
Company Name: Shanghai Boyle Chemical Co., Ltd.  
Tel:
Website: www.boylechem.com
Company Name:   
Tel: 821-50328103-801 18930552037
Website: http://m.approvedhomemanagement.com/ShowSupplierProductsList13285/0.htm
Company Name: Shanghai Hanhong Scientific Co.,Ltd.  
Tel: 021-54306202 13764082696
Website: https://www.hanhongsci.com
Company Name: Chemsky (shanghai) International Co.,Ltd  
Tel: 021-50135380
Website: www.shchemsky.com
Company Name: Lavem Chine Pharm Company  
Tel: 28-86066080 18280039962
Website: http://www.lavemc.com/
Tags:229305-39-9 Related Product Information

  • HomePage | Member Companies | Advertising | Contact us | Previous WebSite | MSDS | CAS Index | CAS DataBase | Privacy | Terms | About Us
  • All products displayed on this website are only for non-medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.
    According to relevant laws and regulations and the regulations of this website, units or individuals who purchase hazardous materials should obtain valid qualifications and qualification conditions.
  • Copyright © 2023 ChemicalBook All rights reserved.