| Identification | Back Directory | [Name]
1H-Indole-6-carbonitrile, 3-[5-bromo-6-[[(2R,3R)-2-(4-fluorophenyl)-3-(hydroxymethyl)-4-morpholinyl]carbonyl]-1-methyl-1H-benzimidazol-2-yl]-1-ethyl-, rel- | [CAS]
2259620-80-7 | [Synonyms]
PDE12-IN-1
1H-Indole-6-carbonitrile, 3-[5-bromo-6-[[(2R,3R)-2-(4-fluorophenyl)-3-(hydroxymethyl)-4-morpholinyl]carbonyl]-1-methyl-1H-benzimidazol-2-yl]-1-ethyl-, rel- | [Molecular Formula]
C31H27BrFN5O3 | [MOL File]
2259620-80-7.mol | [Molecular Weight]
616.48 |
| Chemical Properties | Back Directory | [Boiling point ]
846.6±75.0 °C(Predicted) | [density ]
1.50±0.1 g/cm3(Predicted) | [storage temp. ]
4°C, away from moisture and light | [solubility ]
DMSO : 90 mg/mL (145.99 mM; Need ultrasonic) | [form ]
Solid | [pka]
14.85±0.10(Predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Uses]
PDE12-IN-1 is a potent and selective PDE12 inhibitor with a pIC50 value for enzyme inhibition of 9.1. PDE12-IN-1 increases 2′,5′-linked adenylate polymers (2-5A) levels, and the pEC50 value is 7.7. PDE12-IN-1 shows antiviral activity[1]. | [Biological Activity]
PDE12-IN-1 is a potent and selective PDE12 inhibitor with a pIC50 value for enzyme inhibition of 9.1. PDE12-IN-1 increases 2′,5′-linked adenylate polymers (2-5A) levels, and the pEC50 value is 7.7. PDE12-IN-1 shows antiviral activity[1].
PDE12-IN-1 inhibits the EMCV-induced cytopathic effect in HeLa Ohio cells with a pIC50 of 6.7. PDE12-IN-1 inhibits HeLa Ohio cell proliferation in the absence of EMCV infection with a pIC50 of 5.7. PDE12-IN-1 inhibits the proliferation of both HeLa and HeLaδPDE12 cells with a pIC50 of 5.7. PDE12-IN-1 inhibits HRV infection with a pIC50 of 6.9[1]. | [IC 50]
PDE12: 9.1 (pIC50) | [storage]
4°C, away from moisture and light | [References]
[1]. Wood ER, et al. The Role of Phosphodiesterase 12 (PDE12) as a Negative Regulator of the Innate Immune Response and the Discovery of Antiviral Inhibitors. J Biol Chem. 2015 Aug 7;290(32):19681-96. |
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