| Identification | Back Directory | [Name]
1,3,4-Oxadiazole, 2-[[(2,6-dichlorophenyl)methyl]thio]-5-(1H-pyrrol-2-yl)- | [CAS]
2253744-54-4 | [Synonyms]
Dooku1
1,3,4-Oxadiazole, 2-[[(2,6-dichlorophenyl)methyl]thio]-5-(1H-pyrrol-2-yl)- | [Molecular Formula]
C13H9Cl2N3OS | [MDL Number]
MFCD32174346 | [MOL File]
2253744-54-4.mol | [Molecular Weight]
326.2 |
| Chemical Properties | Back Directory | [Boiling point ]
526.5±60.0 °C(Predicted) | [density ]
1.55±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 125 mg/mL (383.20 mM) | [form ]
Solid | [pka]
13.56±0.50(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Dooku1 is a reversibly Yoda1 antagonist with IC50 value of 1.3 μM and 1.5 μM for 2 μM Yoda1-induced Ca2+ entry HEK 293 cells and HUVECs, respectively. Dooku1 can disrupt Yoda1-induced Piezo1 channel activity and inhibit Yoda1-induced relaxation of aorta. Dooku1 can be used for vascular physiology and disease research[1]. | [Biological Activity]
Dooku1an analog of Yoda1is a potent and selective antagonist of the mechanosensitive Piezo1 channel th at inhibits endogenous Yoda1-activated channels. Dooku1 inhibits relaxation of relaxation of aorta caused by Yoda1. | [in vivo]
Dooku1 (10 μM incubate 20 min) selectively inhibits Yoda1-induced relaxation of aorta of wild-type male C57BL/6 mice[1].
| Animal Model: | wild-type male C57BL/6 mice’s aortic rings[1] | | Dosage: | 10 μM | | Administration: | 20 min | | Result: | Suppressed the Yoda1-induced relaxation. |
| [storage]
Store at +4°C | [References]
[1] Evans EL, et al. Yoda1 analogue (Dooku1) which antagonizes Yoda1-evoked activation of Piezo1 and aortic relaxation. Br J Pharmacol. 2018 May;175(10):1744-1759. DOI:10.1111/bph.14188
[2] Evans EL, et al. Yoda1 analogue (Dooku1) which antagonizes Yoda1-evoked activation of Piezo1 and aortic relaxation. Br J Pharmacol. 2018 May;175(10):1744-1759. DOI:10.1111/bph.14188 |
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