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ChemicalBook--->CAS DataBase List--->2253744-54-4

2253744-54-4

2253744-54-4 Structure

2253744-54-4 Structure
IdentificationBack Directory
[Name]

1,3,4-Oxadiazole, 2-[[(2,6-dichlorophenyl)methyl]thio]-5-(1H-pyrrol-2-yl)-
[CAS]

2253744-54-4
[Synonyms]

Dooku1
1,3,4-Oxadiazole, 2-[[(2,6-dichlorophenyl)methyl]thio]-5-(1H-pyrrol-2-yl)-
[Molecular Formula]

C13H9Cl2N3OS
[MDL Number]

MFCD32174346
[MOL File]

2253744-54-4.mol
[Molecular Weight]

326.2
Chemical PropertiesBack Directory
[Boiling point ]

526.5±60.0 °C(Predicted)
[density ]

1.55±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO: 125 mg/mL (383.20 mM)
[form ]

Solid
[pka]

13.56±0.50(Predicted)
[color ]

White to off-white
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P280-P301+P312-P302+P352-P305+P351+P338
Hazard InformationBack Directory
[Uses]

Dooku1 is a reversibly Yoda1 antagonist with IC50 value of 1.3 μM and 1.5 μM for 2 μM Yoda1-induced Ca2+ entry HEK 293 cells and HUVECs, respectively. Dooku1 can disrupt Yoda1-induced Piezo1 channel activity and inhibit Yoda1-induced relaxation of aorta. Dooku1 can be used for vascular physiology and disease research[1].
[Biological Activity]

Dooku1an analog of Yoda1is a potent and selective antagonist of the mechanosensitive Piezo1 channel th at inhibits endogenous Yoda1-activated channels. Dooku1 inhibits relaxation of relaxation of aorta caused by Yoda1.
[in vivo]

Dooku1 (10 μM incubate 20 min) selectively inhibits Yoda1-induced relaxation of aorta of wild-type male C57BL/6 mice[1].

Animal Model:wild-type male C57BL/6 mice’s aortic rings[1]
Dosage:10 μM
Administration:20 min
Result:Suppressed the Yoda1-induced relaxation.
[storage]

Store at +4°C
[References]

[1] Evans EL, et al. Yoda1 analogue (Dooku1) which antagonizes Yoda1-evoked activation of Piezo1 and aortic relaxation. Br J Pharmacol. 2018 May;175(10):1744-1759. DOI:10.1111/bph.14188
[2] Evans EL, et al. Yoda1 analogue (Dooku1) which antagonizes Yoda1-evoked activation of Piezo1 and aortic relaxation. Br J Pharmacol. 2018 May;175(10):1744-1759. DOI:10.1111/bph.14188
Spectrum DetailBack Directory
[Spectrum Detail]

1,3,4-Oxadiazole, 2-[[(2,6-dichlorophenyl)methyl]thio]-5-(1H-pyrrol-2-yl)-(2253744-54-4)1HNMR
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