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ChemicalBook--->CAS DataBase List--->2245255-65-4

2245255-65-4

2245255-65-4 Structure

2245255-65-4 Structure
IdentificationBack Directory
[Name]

GSK2807
[CAS]

2245255-65-4
[Synonyms]

GSK2807
GSK-2807 free base
GSK-2807 (GSK 2807
[Molecular Formula]

C19H32N8O5
[MOL File]

2245255-65-4.mol
[Molecular Weight]

452.52
Chemical PropertiesBack Directory
[Boiling point ]

751.7±70.0 °C(Predicted)
[density ]

1.57±0.1 g/cm3(Predicted)
[pka]

2.08±0.10(Predicted)
Hazard InformationBack Directory
[Uses]

GSK2807 is a potent and selective SAM-competitive inhibitor of SMYD3, exhibiting a Ki value of 14 nM, and it may be useful for cancer treatment by preventing the methylation of MEKK2.
[References]

[1] Structure-Based Design of a Novel SMYD3 Inhibitor that Bridges the SAM-and MEKK2-Binding Pockets DOI:10.1016/j.str.2016.03.010
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