| Identification | Back Directory | [Name]
L-Tryptophan, L-cysteinyl-L-alanyl-L-cysteinyl-L-phenylalanyl-L-threonyl-L-tyrosyl-L-lysyl-L-α-aspartyl-L-lysyl-L-α-glutamyl-L-cysteinyl-L-valyl-L-tyrosyl-L-tyrosyl-L-cysteinyl-L-histidyl-L-leucyl-L-α-aspartyl-L-isoleucyl-L-isoleucyl-, cyclic (1→15),(3→11)-bis(disulfide) | [CAS]
2243207-08-9 | [Synonyms]
L-Tryptophan, L-cysteinyl-L-alanyl-L-cysteinyl-L-phenylalanyl-L-threonyl-L-tyrosyl-L-lysyl-L-α-aspartyl-L-lysyl-L-α-glutamyl-L-cysteinyl-L-valyl-L-tyrosyl-L-tyrosyl-L-cysteinyl-L-histidyl-L-leucyl-L-α-aspartyl-L-isoleucyl-L-isoleucyl-, cyclic (1→15),(3→11)-bis(disulfide) | [Molecular Formula]
C120H166N26O32S4 | [MOL File]
2243207-08-9.mol | [Molecular Weight]
2613.02 |
| Hazard Information | Back Directory | [Uses]
[Ala2] Endothelin-3, human is a linear analog of endothelin-3 (ET-3) where substitution of Ala for Cys residues. TE-3 is a vasoactive peptide, produced by human rhabdomyosarcoma cell lines, whereas it is not expressed by human sarcoma cell lines of non-muscle origin. ET-3 acts as a paracrine factor, since it promotes migration of endothelial cells[1][2]. | [References]
[1] Palladini A, et al. Endothelin-3 production by human rhabdomyosarcoma: a possible new marker with a paracrine role. Eur J Cancer. 2006 Mar;42(5):680-7. DOI:10.1016/j.ejca.2005.11.024
[2] Davenport AP, et al. Endothelin. Pharmacol Rev. 2016 Apr;68(2):357-418. |
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