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ChemicalBook--->CAS DataBase List--->2229974-83-6

2229974-83-6

2229974-83-6 Structure

2229974-83-6 Structure
IdentificationBack Directory
[Name]

1H-Isoindole-1,3(2H)-dione, 4-[[2-[4-[6-[(6-acetyl-8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-1-piperazinyl]-2-oxoethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-
[CAS]

2229974-83-6
[Synonyms]

MS140
XY028-140
1H-Isoindole-1,3(2H)-dione, 4-[[2-[4-[6-[(6-acetyl-8-cyclopentyl-7,8-dihydro-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]-3-pyridinyl]-1-piperazinyl]-2-oxoethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-
[Molecular Formula]

C39H40N10O7
[MDL Number]

MFCD34187227
[MOL File]

2229974-83-6.mol
[Molecular Weight]

760.8
Chemical PropertiesBack Directory
[density ]

1.482±0.06 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO : 5.56 mg/mL (7.31 mM; ultrasonic and warming and heat to 60°C)
[form ]

Solid
[pka]

10.74±0.40(Predicted)
[color ]

White to yellow
Hazard InformationBack Directory
[Biological Activity]

XY028-140 is a selective CDK4/CDK6 degrader. XY028-140 inhibits both CDK4/6 expression and CDK4/6 activity in cancer cells[1]. A375 melanoma and T47D breast cancer cells are treated with 0.3 or 1 μμ XY028-140 for 24 hours. XY028-140 inhibits both CDK4/6 expression and CDK4/6 activity[1]. T47D breast cancer cells are treated with 0.03, 0.1, 0.3, 1, or 3 μμ XY028-140 for 11 days. XY028-140 inhibits cancer cell proliferation in breast cancer cells[1].
[References]

[1]. Jian Jin, et al. Compositions and methods for treating cdk4/6-mediated cancer. WO2018106870A1.
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