| Identification | Back Directory | [Name]
1-LINOLEOYL-2-HYDROXY-SN-GLYCERO-3-PHOSPHORYLCHOLINE | [CAS]
22252-07-9 | [Synonyms]
Lysophosphatidylcholine 18:2
1-Linoleoyl-2-Hydroxy-sn-glycero-3-PC
1-LINOLEOYL-2-HYDROXY-SN-GLYCERO-3-PHOSPHORYLCHOLINE | [Molecular Formula]
C26H50NO7P | [MDL Number]
MFCD02259125 | [MOL File]
22252-07-9.mol | [Molecular Weight]
519.66 |
| Hazard Information | Back Directory | [Uses]
Lysophosphatidylcholine 18:2 (1-Linoleoyl-2-Hydroxy-sn-glycero-3-PC), a lysophospholipid, is a potential biomarker identified from insulin resistance (IR) polycystic ovary syndrome (PCOS). Low plasma Lysophosphatidylcholine 18:2 also has been shown to predict impaired glucose tolerance, insulin resistance, type 2 diabetes, coronary artery disease, and memory impairment[1][2]. | [Definition]
ChEBI: 1-linoleoyl-sn-glycero-3-phosphocholine is a lysophosphatidylcholine 18:2 in which the acyl group at position 1 is (9Z,12Z)-octadecadienoyl. It has a role as a mouse metabolite. It is a lysophosphatidylcholine(18:2/0:0) and a linoleoyl-sn-glycero-3-phosphocholine. It is functionally related to a linoleic acid. | [Biological Activity]
1-Linoleoyl-2-hydroxy-sn-glycero-3-PC (LGPC) is a lysophospholipid containing linoleic acid at the sn-1 position that has been found in mouse heart, lung, liver, spleen, kidney, plasma, and serum.1 Serum levels of LGPC decrease with increasing insulin resistance and dysglycemia in humans.2 | [IC 50]
Human Endogenous Metabolite | [References]
1.Okudaira, M., Inoue, A., Shuto, A., et al.Separation and quantification of 2-acyl-1-lysophospholipids and 1-acyl-2-lysophospholipids in biological samples by LC-MS/MSJ. Lipid Res.55(10)2178-2192(2014)
2.Gall, W.E., Beebe, K., Lawton, K.A., et al.α-Hydroxybutyrate is an early biomarker of insulin resistance and glucose intolerance in a nondiabetic populationPLoS One5(5)e10883(2010)
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