| Identification | Back Directory | [Name]
1-Piperazinecarboxylic acid, 4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-, 1,1-dimethylethyl ester | [CAS]
2222114-64-7 | [Synonyms]
tert-butyl 4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperazine-1-carboxylate
1-Piperazinecarboxylic acid, 4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-, 1,1-dimethylethyl ester | [Molecular Formula]
C22H26N4O6 | [MDL Number]
MFCD32705088 | [MOL File]
2222114-64-7.mol | [Molecular Weight]
442.46 |
| Chemical Properties | Back Directory | [Boiling point ]
674.6±55.0 °C(Predicted) | [density ]
1.373±0.06 g/cm3(Predicted) | [solubility ]
DMSO : 41.67 mg/mL (94.18 mM; Need ultrasonic) | [form ]
Solid | [pka]
10.83±0.40(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
Thalidomide-piperazine-Boc is an intermediate that can be used in the synthesis of B-cell lymphoma 6 protein (BCL6) PROTAC[1]. | [Biological Activity]
Thalidomide-piperazine-Boc is an intermediate that can be used in the synthesis of B-cell lymphoma 6 protein (BCL6) PROTAC[1]. | [IC 50]
Cereblon | [References]
[1]. Michael Berlin, et al. Bifunctional molecules containing an e3 ubiquitine ligase binding moiety linked to a bcl6 targeting moiety. WO2021077010A1. |
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