| Identification | Back Directory | [Name]
1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-fluoro-6-(1-piperazinyl)- | [CAS]
2222114-22-7 | [Synonyms]
2-(2,6-dioxopiperidin-3-yl)-5-fluoro-6-(piperazin-1-yl)isoindoline-1,3-dione
1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-5-fluoro-6-(1-piperazinyl)- | [Molecular Formula]
C17H17FN4O4 | [MDL Number]
MFCD32203463 | [MOL File]
2222114-22-7.mol | [Molecular Weight]
360.34 |
| Chemical Properties | Back Directory | [Boiling point ]
652.2±55.0 °C(Predicted) | [density ]
1.475±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
10.59±0.40(Predicted) | [color ]
Off-white to light green |
| Hazard Information | Back Directory | [Uses]
Thalidomide-Piperazine 5-fluoride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1]. | [IC 50]
Cereblon | [References]
[1] Hexiang Wang, et al. Degradation of androgen receptor (ar) by conjugation of ar antagonists with e3 ligase ligand and methods of use. WO2021058017A1. |
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