| Hazard Information | Back Directory | [Uses]
PTP1B-IN-24 (Compound 9) is a reversible PTP1B inhibitor with an IC50 value of 1.4 μM, and PTP1B-IN-24 can enhance the thermal stability of PTP1B. PTP1B-IN-24 can restore PA- (HY-N0830) induced insulin resistance by increasing the phosphorylation levels of IRS1 and AKT[1]. | [IC 50]
Akt: 1.4 μM (IC50) | [References]
[1] Zheng Y, et al. New chromone derivatives bearing thiazolidine-2,4-dione moiety as potent PTP1B inhibitors: Synthesis and biological activity evaluation. Bioorg Chem. 2024 Feb;143:106985. DOI:10.1016/j.bioorg.2023.106985 |
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