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ChemicalBook--->CAS DataBase List--->220998-10-7

220998-10-7

220998-10-7 Structure

220998-10-7 Structure
IdentificationBack Directory
[Name]

Elomotecan
[CAS]

220998-10-7
[Synonyms]

Elomotecan
(R)-EloMotecan
(5R)-9-Chloro-5-ethyl-1,4,5,13-tetrahydro-5-hydroxy-10-methyl-12-[(4-methyl-1-piperidinyl)methyl]-3H,15H-oxepino[3',4':6,7]indolizino[1,2-b]quinoline-3,15-dione
3H,15H-Oxepino[3',4':6,7]indolizino[1,2-b]quinoline-3,15-dione,9-chloro-5-ethyl-1,4,5,13-tetrahydro-5-hydroxy-10-methyl-12-[(4-methyl-1-piperidinyl)methyl]-,(5R)-
[Molecular Formula]

C29H32ClN3O4
[MOL File]

220998-10-7.mol
[Molecular Weight]

522.04
Chemical PropertiesBack Directory
[Boiling point ]

821.3±65.0 °C(Predicted)
[density ]

1.39±0.1 g/cm3(Predicted)
[pka]

12.29±0.20(Predicted)
Hazard InformationBack Directory
[Uses]

Elomotecan (BN 80927 free base) is a potent inhibitor of topoisomerases I and II. Elomotecan is a camptothecin analog belonging to the homocamptothecin family (hCPT). Elomotecan reduces the proliferation of different tumor cells with higher potency than other anticancer agents of reference targeting topoisomerases I and II[1].
[IC 50]

Topoisomerase I; Topoisomerase II
[References]

[1] Trocóniz IF, et al. Population pharmacokinetic/pharmacodynamic modeling of drug-induced adverse effects of a novel homocamptothecin analog, elomotecan (BN80927), in a Phase I dose finding study in patients with advanced solid tumors. Cancer Chemother Pharmacol. 2012;70(2):239-250. DOI:10.1007/s00280-012-1906-y
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