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ChemicalBook--->CAS DataBase List--->2209911-80-6

2209911-80-6

2209911-80-6 Structure

2209911-80-6 Structure
IdentificationBack Directory
[Name]

1H-Pyrrole-3-methanamine, 5-(2-fluorophenyl)-1-[[3-(3-methoxypropoxy)phenyl]sulfonyl]-N-methyl-, hydrochloride (1:1)
[CAS]

2209911-80-6
[Synonyms]

P-CAB agent 2 hydrochloride
1H-Pyrrole-3-methanamine, 5-(2-fluorophenyl)-1-[[3-(3-methoxypropoxy)phenyl]sulfonyl]-N-methyl-, hydrochloride (1:1)
[Molecular Formula]

C22H26ClFN2O4S
[MOL File]

2209911-80-6.mol
[Molecular Weight]

468.97
Chemical PropertiesBack Directory
[form ]

Solid
[color ]

Off-white to light yellow
Hazard InformationBack Directory
[Uses]

P-CAB agent 2 hydrochloride is a potent and orally active potassium-competitive acid blocker and a gastric acid secretion inhibitor. P-CAB agent 2 hydrochloride inhibits H+/K+-ATPase activity with an IC50 value of <100 nM. P-CAB agent 2 hydrochloride inhibits the hERG potassium channel with an IC50 value of 18.69 M. P-CAB agent 2 hydrochloride shows no acute toxicity and inhibits histamine (HY-B1204)-induced gastric acid secretion[1].
[in vivo]

P-CAB agent 2 hydrochloride (example 1) inhibits histamine (HY-B1204)-induced gastric acid secretion in SD rats[1].
P-CAB agent 2 hydrochloride (600, 2000 mg/kg; p.o.; once) shows no acute toxicity and 600mg/kg shows no significant effect on animal body weight in SD rats[1].

Animal Model:180-220 g, SPF grade, male SD rats[1]
Dosage:2 mg/kg
Administration:P.o.; once
Result:Inhibited histamine-induced gastric acid secretion with the acid suppression rate of 55.4%.
[References]

[1] YinLin Qin, et al. Pyrrole sulfonyl derivative, and preparation method and medical use thereof. WO2016119505A1.
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