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ChemicalBook--->CAS DataBase List--->220619-73-8

220619-73-8

220619-73-8 Structure

220619-73-8 Structure
IdentificationBack Directory
[Name]

VTP 194204
[CAS]

220619-73-8
[Synonyms]

NRX-4204
IRX-4204
iso IRX-A
VTP 194204
NRX 194204
2,4-Pentadienoic acid, 3-methyl-5-[(1S,2S)-2-methyl-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)cyclopropyl]-, (2E,4E)-
[Molecular Formula]

C24H32O2
[MDL Number]

MFCD03423861
[MOL File]

220619-73-8.mol
[Molecular Weight]

352.51
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
[form ]

Solid
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

iso IRX-A is used in the preparation of rexinoids and compositions containing them for immune modulation and treatment of cancer.
[in vivo]

AGN194204 (NRX194204; 30-60 mg/kg; oral administration; daily; for 15 weeks; female A/J mice) treatment significantly reduces the number and size of tumors on the surface of the lungs and reduces the total tumor volume per slide by 64% to 81% compared with the control group[1].

Animal Model:Female A/J mice with vinyl carbamate[1]
Dosage:30 mg/kg, 60 mg/kg
Administration:Oral administration; daily; for 15 weeks
Result:Significantly reduced the number and size of tumors on the surface of the lungs and reduced the total tumor volume per slide by 64% to 81% compared with the control group.
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