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ChemicalBook--->CAS DataBase List--->2173582-08-4

2173582-08-4

2173582-08-4 Structure

2173582-08-4 Structure
IdentificationBack Directory
[Name]

M-525 (M525)
[CAS]

2173582-08-4
[Synonyms]

M-525 (M525)
[Molecular Formula]

C39H51FN6O5S
[MDL Number]

MFCD34469323
[MOL File]

2173582-08-4.mol
[Molecular Weight]

734.92
Chemical PropertiesBack Directory
[Boiling point ]

902.3±65.0 °C(Predicted)
[density ]

1.31±0.1 g/cm3(Predicted)
[pka]

11.70±0.40(Predicted)
Hazard InformationBack Directory
[Description]

M-525 is a first-in-class, highly potent, irreversible small-molecule inhibitor of the menin-MLL interaction.
[Uses]

M-525 is a first-in-class, highly potent, irreversible and covalent menin-MLL protein-protein interaction inhibitor. M-525 binds to menin with an IC50 of 3 nM and achieves low nanomolar potencies in cell growth inhibition and in suppression of MLL regulated gene expression in MLL leukemia cells. Anti-leukemia activity[1].
[References]

[1] Xu S, et al. Design of the First-in-Class, Highly Potent Irreversible Inhibitor Targeting the Menin-MLL Protein-Protein Interaction. Angew Chem Int Ed Engl. 2018 Feb 5;57(6):1601-1605. DOI:10.1002/anie.201711828
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