| Identification | Back Directory | [Name]
STING agonist-3 | [CAS]
2138299-29-1 | [Synonyms]
STING agonist-3
STING agonist compound 3
1H-Benzimidazole-5-carboxamide, 1-[(2E)-4-[5-(aminocarbonyl)-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-1H-benzimidazol-1-yl]-2-buten-1-yl]-2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-7-(3-hydroxypropoxy)- | [Molecular Formula]
C37H42N12O6 | [MDL Number]
MFCD32669798 | [MOL File]
2138299-29-1.mol | [Molecular Weight]
750.81 |
| Chemical Properties | Back Directory | [density ]
1.47±0.1 g/cm3(Predicted) | [solubility ]
DMSO: 40 mg/ml, sonicated | [form ]
A solid | [pka]
11.86±0.43(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
STING agonist-3, extracted from patent WO2017175147A1 (example 10), is a selective and non-nucleotide small-molecule?STING?agonist with a pEC50 and pIC50 of 7.5 and 9.5, respectively. STING agonist-3 has durable anti-tumor effect and tremendous potential to improve treatment of cancer[1]. | [References]
[1] Adam Kenneth, et al. Heterocyclic amides useful as protein modulators.patent WO2017175147A1
[2] Ramanjulu JM, Pesiridis GS, Yang J, et al. Design of amidobenzimidazole STING receptor agonists with systemic activity [published correction appears in Nature. 2019 Jun;570(7761):E53. doi: 10.1038/s41586-019-1265-5]. Nature. 2018;564(7736):439-443. DOI:10.1038/s41586-018-0705-y |
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