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ChemicalBook--->CAS DataBase List--->2126784-39-0

2126784-39-0

2126784-39-0 Structure

2126784-39-0 Structure
IdentificationBack Directory
[Name]

2(1H)-Pyridinone, 1-(4-fluorophenyl)-4-[(2S)-2-phenoxypropoxy]-
[CAS]

2126784-39-0
[Synonyms]

2(1H)-Pyridinone, 1-(4-fluorophenyl)-4-[(2S)-2-phenoxypropoxy]-
[Molecular Formula]

C20H18FNO3
[MOL File]

2126784-39-0.mol
[Molecular Weight]

339.36
Chemical PropertiesBack Directory
[Boiling point ]

519.9±50.0 °C(Predicted)
[density ]

1.25±0.1 g/cm3(Predicted)
[form ]

Solid
[pka]

-1.25±0.63(Predicted)
[color ]

Off-white to light yellow
Hazard InformationBack Directory
[Description]

VU 6010572 is a negative allosteric modulator (NAM) for mGlu. VU 6010572 has an IC50 of 245 nM for mGlu3 with high selectivity among all mGlu receptors. VU 6010572 is highly CNS penetrant.
[Uses]

VU6010572 is a potent and selective mGlu3 negative allosteric modulator with IC50 of 245 nM. VU6010572 is highly CNS penetrant[1][2].
[in vivo]

VU6010572 (3 mg/kg; i.p.) shows robust efficacy[1].
VU6010572 (3 mg/kg; i.p.; 45 minutes) produces lasting anxiolytic-like behavioral effects[2].

Animal Model:CD-1 mice[1]
Dosage:3 mg/kg
Administration:I.p.
Result:Showed robust efficacy.
Animal Model:Rats[2]
Dosage:3 mg/kg
Administration:I.p.; 45 minutes
Result:Produced lasting anxiolytic-like behavioral effects.
[IC 50]

mGluR3: 245 nM (IC50)
[References]

[1] Engers JL, et al. Design and Synthesis of N-Aryl Phenoxyethoxy Pyridinones as Highly Selective and CNS Penetrant mGlu3 NAMs. ACS Med Chem Lett. 2017;8(9):925-930. Published 2017 Aug 15. DOI:10.1021/acsmedchemlett.7b00249
[2] Ryan E. Tyler1, et al. The effects of predator odor (TMT) exposure and mGlu3 NAM pretreatment on lasting behavioral and molecular adaptations in the insular cortex and BNST
2126784-39-0 suppliers list
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Tel: +17819995354 , +17819995354
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Tel: 021-13816613772 13816613772
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Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Website: https://www.targetmol.cn/
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