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ChemicalBook--->CAS DataBase List--->2114324-48-8

2114324-48-8

2114324-48-8 Structure

2114324-48-8 Structure
IdentificationBack Directory
[Name]

1-Piperidinecarboxylic acid, 3-[(methylsulfonyl)amino]-2-[[(cis-4-phenylcyclohexyl)oxy]methyl]-, methyl ester, (2R,3S)-
[CAS]

2114324-48-8
[Synonyms]

Danavorexton
1-Piperidinecarboxylic acid, 3-[(methylsulfonyl)amino]-2-[[(cis-4-phenylcyclohexyl)oxy]methyl]-, methyl ester, (2R,3S)-
[Molecular Formula]

C21H32N2O5S
[MOL File]

2114324-48-8.mol
[Molecular Weight]

424.55
Chemical PropertiesBack Directory
[storage temp. ]

Store at -20°C
[form ]

Solid
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

Danavorexton (TAK-925) is an orexin receptor agonist with brain permeability. Danavorexton induces a physiological pattern of OX2R activation in vitro to wake up sleepy mice and improve sleepiness symptoms[1][2][3][4].
[in vivo]

Danavorexton (1, 10 mg/kg or 1, 3 mg/kg, subcutaneous injection) dose-dependent enhanced arousal in common marmosets and cynomolgus monkeys[2].

Animal Model:Common marmosets and cynomolgus monkeys models[2]
Dosage:1, 10 mg/kg (1, 3 mg/kg)
Administration: s.c.
Result:Decreased SWS I (Sleeping With Sirens I), SWS II (Sleeping With Sirens II) and REM (Rapid Eye Movement) sleep time.
[References]

[1] International Nonproprietary Names for Pharmaceutical Substances (INN). WHO Drug Information, Vol. 34, No. 2, 2020.
[2] Evans R, et al. Orexin 2 receptor-selective agonist danavorexton (TAK-925) promotes wakefulness in non-human primates and healthy individuals. J Sleep Res. 2023 Oct;32(5):e13878 DOI:10.1111/jsr.13878
[3] Ishikawa T, et al. Danavorexton, a selective orexin 2 receptor agonist, provides a symptomatic improvement in a narcolepsy mouse model. Pharmacol Biochem Behav. 2022 Oct;220:173464. DOI:10.1016/j.pbb.2022.173464
[4] Fujimoto T, et al. Discovery of TAK-925 as a Potent, Selective, and Brain-Penetrant Orexin 2 Receptor Agonist. ACS Med Chem Lett. 2022 Feb 4;13(3):457-462. DOI:10.1021/acsmedchemlett.1c00626
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