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ChemicalBook--->CAS DataBase List--->2108830-08-4

2108830-08-4

2108830-08-4 Structure

2108830-08-4 Structure
IdentificationBack Directory
[Name]

TH 1834
[CAS]

2108830-08-4
[Synonyms]

TH 1834
2H-Tetrazole-2-acetic acid, 5-[4-[[(2-phenylethyl)[4-[4-(1-pyrrolidinylmethyl)phenoxy]butyl]amino]methyl]phenyl]-
[Molecular Formula]

C33H40N6O3
[MDL Number]

MFCD32701916
[MOL File]

2108830-08-4.mol
[Molecular Weight]

568.71
Chemical PropertiesBack Directory
[Boiling point ]

750.4±70.0 °C(Predicted)
[density ]

1.21±0.1 g/cm3(Predicted)
[form ]

Solid
[pka]

2.91±0.10(Predicted)
[color ]

White to light yellow
Hazard InformationBack Directory
[Uses]

TH1834 is a specific Tip60 (KAT5) histone acetyltransferase (HAT) inhibitor. TH1834 induces apoptosis and increases DNA damage in breast cancer. TH1834 does not affect the activity of related histone acetyltransferase MOF. Anticancer activity[1].
[IC 50]

TIP60
[References]

[1] Gao C, et al. Rational design and validation of a Tip60 histone acetyltransferase inhibitor. Sci Rep. 2014 Jun 20;4:5372. DOI:10.1038/srep05372
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