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ChemicalBook--->CAS DataBase List--->210755-45-6

210755-45-6

210755-45-6 Structure

210755-45-6 Structure
IdentificationBack Directory
[Name]

CP 471,474
[CAS]

210755-45-6
[Synonyms]

PF-1626077
CP 471,474
2-(4-(4-Fluorophenoxy)phenylsulfonamido)-N-hydroxy-2-methylpropanamide
2-[[[4-(4-Fluorophenoxy)phenyl]sulfonyl]amino]-N-hydroxy-2-methylpropanamide
Propanamide, 2-[[[4-(4-fluorophenoxy)phenyl]sulfonyl]amino]-N-hydroxy-2-methyl-
[Molecular Formula]

C16H17FN2O5S
[MDL Number]

MFCD16618408
[MOL File]

210755-45-6.mol
[Molecular Weight]

368.38
Chemical PropertiesBack Directory
[Melting point ]

135-137°C (dec.)
[density ]

1.375±0.06 g/cm3(Predicted)
[storage temp. ]

room temp
[solubility ]

DMSO: ≥20mg/mL
[form ]

powder
[pka]

9.33±0.50(Predicted)
[color ]

white to off-white
Safety DataBack Directory
[Hazard Codes ]

Xn
[Risk Statements ]

22
[WGK Germany ]

1
Hazard InformationBack Directory
[Description]

CP 471,474 is a broad-spectrum inhibitor of matrix metalloproteinases (MMPs) with IC50 values of 0.7, 16, 13, and 0.9 nM for MMP-2, MMP-3, MMP-9, and MMP-13, respectively. It is selective for these MMPs over MMP-1 (IC50 = 1,170 nM). CP 471,474 reduces left ventricular enlargement and decreases the incidence of cardiac rupture in mouse models of myocardial infarction when administered at doses of 120 mg/kg twice per day and 240 mg/kg per day, respectively.
[Chemical Properties]

White Solid
[Uses]

A broad spectrum inhibitor of matrix metalloproteinases that attenuates early left ventricular dilation after experimental myocardial infarction in mice. Studies show that it also inhibits cigarette smoke-induced lung inflammation and the progression of emphysema in guinea pig models.
[Biochem/physiol Actions]

CP-471474 is a broad spectrum inhibitor of matrix metalloproteinases. CP-471474 has a low nM IC50 efficacy for MMP-2, MMP-3, MMP-9, and MMP-13. CP-471474 has low potency against MMP-1 (IC50 > 1 uM). CP-471474 prevents left ventricular remodeling after experimental myocardial infarction in mice. CP-471474 also inhibits cigarette smoke-induced lung inflammation and the progression of emphysema in guinea pig models.
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