| Identification | Back Directory | [Name]
(S)-2-AMINO-(1-IMINOETHYLAMINO)-5-THIOHEPTANOIC ACID | [CAS]
210354-22-6 | [Synonyms]
GW274150
GW274150
(GW-274150
Acetylcysteine Impurity 4
4-(2-acetamidoethylthio)-2-aminobutanoic acid
S-[2-[(1-iminoethyl)amino]ethyl]-L-Homocysteine
4-(2-acetamidoethylsulfanyl)-2-aminobutanoicacid
L-Homocysteine, S-[2-[(1-iminoethyl)amino]ethyl]-
(S)-2-AMINO-(1-IMINOETHYLAMINO)-5-THIOHEPTANOIC ACID | [Molecular Formula]
C8H17N3O2S | [MDL Number]
MFCD02683945 | [MOL File]
210354-22-6.mol | [Molecular Weight]
219.3 |
| Chemical Properties | Back Directory | [Boiling point ]
392.3±52.0 °C(Predicted) | [density ]
1.30±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Solid | [pka]
2.22±0.10(Predicted) | [color ]
White to off-white | [Water Solubility ]
Water : ≥ 62 mg/mL (282.72 mM) |
| Hazard Information | Back Directory | [Uses]
GW274150 is a potent, selective, orally active and NADPH-dependent inhibitor of human inducible nitric oxide synthase (iNOS) (IC50=2.19 μM; Kd=40 nM) and rat iNOS (ED50=1.15 μM). GW274150 also displays less potency for both humans or rats endothelial NOS (eNOS) and neuronal NOS (nNOS). GW274150 exerts a protective role in an acute model of lung injury inflammation[1][2]. | [in vivo]
GW274150 is a long-acting (5 h half-life in rats) iNOS inhibitor and is able to inhibit LPS-mediated increase in plasma NO2-, NO3- levels 14 h after single intraperitoneal dose (ED50=3 mg/kg)[2].GW274150 (intraperitoneal injection; 2.5, 5, and 10 mg/kg; before carrageenan injection) reduces the degree of lung injury induced by carrageenan in a dose-related fashion. Oedema formation and PMNs infiltration in the pleural cavity are also significantly attenuated in a dose-related manner in rats[2].GW274150 (oral adminstration; 30 mg/kg; twice daily; 7 days) leads to significant neuroprotection, However, it displays a bell-shaped neuroprotective profile, being ineffective at high doses in 6-OHDA rat model of Parkinson disease (PD)[3]. | Animal Model: | SD-rat[2] | | Dosage: | 2.5, 5 and 10 mg/kg; single dose | | Administration: | Intraperitoneal?injection 5 min before carrageenan injection | | Result: | Exerted a protective role in an acute model of inflammation, carrageenan-induced lung injury.
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| [IC 50]
iNOS | [storage]
Store at -20°C | [References]
[1] Alderton WK, et al. GW274150 and GW273629 are potent and highly selective inhibitors of inducible nitric oxide synthase in vitro and in vivo.Br J Pharmacol. 2005 Jun;145(3):301-12. DOI:10.1038/sj.bjp.0706168
[2] Dugo L, et al. Effects of GW274150, a novel and selective inhibitor of iNOS activity, in acute lung inflammation. Br J Pharmacol. 2004 Mar;141(6):979-87. Epub 2004 Feb DOI:10.1038/sj.bjp.0705683
[3] Broom L, et al. Neuroprotection?by the?selective?iNOS?inhibitor?GW274150?in a?model?of?Parkinson?disease.Free Radic Biol Med.?2011 Mar 1;50(5):633-40. DOI:10.1016/j.freeradbiomed.2010.12.026 |
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| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
| Company Name: |
DC Chemicals
|
| Tel: |
021-8447131 13564518121 |
| Website: |
m.approvedhomemanagement.com/showsupplierproductslist927327/0.htm |
|