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ChemicalBook--->CAS DataBase List--->210344-95-9

210344-95-9

210344-95-9 Structure

210344-95-9 Structure
IdentificationBack Directory
[Name]

Z-DEVD-FMK
[CAS]

210344-95-9
[Synonyms]

S7312
CS-1505
CTK8E8674
AG-B-56189
Z-DEVD-FMK
CASPASE-3, INHIBITOR
CASPASE-3 INHIBITOR2
Z-DEVD-FMK USP/EP/BP
CASPASE-3 INHIBITOR II
Z-DEVD-FLUOROMETHYLKETONE
Z-D(OME)E(OME)VD(OME)-FMK
CASPASE3/CPP32 INHIBITOR W-3
Caspase-2 Inhibitor Z-VDVAD-FMK
Z-ASP-GLU-VAL-ASP-FLUOROMETHYLKETONE
Z-ASP(OME)-GLU(OME)-VAL-ASP(OME)-FMK
Z-ASP(OME)-GLU(OME)-VAL-ASP(OME)-CH2F
Z-D(OME)E(OME)VD(OME) FLUOROMETHYLKETONE
CASPASE-3 INHIBITOR (FLUOROMETHYLKETONE)
Z-ASP(OME)-GLU(OME)-VAL-ASP(OME)-FLUOROMETHYLKETONE
Caspase-3 Inhibitor II - CAS 210344-95-9 - Calbiochem
Z-ASP(OME)-GLU(OME)-VAL-DL-ASP(OME)-FLUOROMETHYLKETONE
BENZYLOXYCARBONYL-ASP(OME)-GLU(OME)-VAL-ASP(OME)-FLUOROMETHYLKETONE
CASPASE-3 INHIBITOR II; 210344-95-9; CASPASE-3 INHIBITOR; CTK8E8674; AG-B-56189; S7312;CASPASE-3 INHIBITOR;210344-95-9
L-Valinamide, N-[(phenylmethoxy)carbonyl]-L-α-aspartyl-L-α-glutamyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-, 1,2-dimethyl ester
N-[(Phenylmethoxy)carbonyl]-L-alpha-aspartyl-L-alpha-glutamyl-N-[(1S)-3-fluoro-1-(2-methoxy-2-oxoethyl)-2-oxopropyl]-L-valinamide 1,2-dimethyl ester
[Molecular Formula]

C30H41FN4O12
[MDL Number]

MFCD01074978
[MOL File]

210344-95-9.mol
[Molecular Weight]

668.66
Chemical PropertiesBack Directory
[Boiling point ]

914.2±65.0 °C(Predicted)
[density ]

1.260±0.06 g/cm3(Predicted)
[storage temp. ]

Inert atmosphere,Store in freezer, under -20°C
[solubility ]

DMSO/DMF: ≥20 mM
[form ]

White to slightly brown solid
[pka]

10.26±0.46(Predicted)
[color ]

White to off-white
Safety DataBack Directory
[WGK Germany ]

3
Hazard InformationBack Directory
[Uses]

Z-DEVD-FMK is an irrversible caspase-3 inhibitor used as an anaesthetic agent. In addition, it is proposed to increase the longevity of platelet storage.
[Definition]

ChEBI: Z-DEVD-FMK is a tetrapeptide consisting of Fmoc-L-aspartic acid 4-methyl ester, methyl L-alpha-glutamic acid 5-methyl ester, L-valine and the fluoromethyl ketone derived from the 1-carboxy group of L-aspartic acid 4-methyl ester coupled in sequence. It is a specific, irreversible caspase-3 inhibitor that also shows potent inhibition of caspase-6, caspase-7, caspase-8, and caspase-10. It has a role as an apoptosis inhibitor, an EC 3.4.22.56 (caspase-3) inhibitor and a neuroprotective agent.
[General Description]

A potent, cell-permeable, and irreversible inhibitor of caspase-3 as well as caspase-6, caspase-7, caspase-8, and caspase-10. When using with purified native or recombinant enzyme, pretreatment with an esterase is required. A 5 mM (250 μg/75 μl) solution of Z-DEVD-FMK (Cat. No. 264156) in DMSO is also available.
[Biological Activity]

Cell-permeable, irreversible inhibitor of caspase-3/CPP32; inhibits tumor cell apoptosis. Neuroprotective in rat hippocampus following seizures in vivo .
[Biochem/physiol Actions]

Cell permeable: yes
[target]

Caspase-3
[References]

1. garcia-calvo m, peterson ep, leiting b, ruel r, nicholson dw, thornberry na (1998) inhibition of human caspases by peptidebased and macromolecular inhibitors. j biol chem 273:32608–32613 2. thornberry na, rano ta, peterson ep, rasper dm, timkey t, garcia-calvo m, houtzager vm, nordstrom pa, roy s, vaillancourt jp, chapman kt, nicholson dw (1997) a combinatorial approach defines specificities of members of the caspase family and granzyme b. functional relationships established for key mediators of apoptosis. j biol chem 272:17907–17911 3. yakovlev ag, knoblach sm, fan l, fox gb, goodnight r, faden ai (1997) activation of cpp32-like caspases contributes to neuronal apoptosis and neurological dysfunction after traumatic brain injury. j neurosci 17:7415–7424 4. clark rs, kochanek pm, watkins sc, chen m, dixon ce, seidberg na, melick j, loeffert je, nathaniel pd, jin kl, graham sh (2000) caspase-3 mediated neuronal death after traumatic brain injury in rats. j neurochem 74:740–753 5. s. m. knoblach, d. a. alroy et al, caspase inhibitor z-devd-fmk attenuates calpain and necrotic cell death in vitro and after traumatic brain injury, journal of cerebral blood flow & metabolism 24:1119–1132.
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