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ChemicalBook--->CAS DataBase List--->2098-66-0

2098-66-0

2098-66-0 Structure

2098-66-0 Structure
IdentificationBack Directory
[Name]

Cyproterone
[CAS]

2098-66-0
[Synonyms]

SH-881
SH-80881
cyproteron
CYPROTERONE
Cyproterone-d5
ro-17-hydroxy-
Cyproterone USP/EP/BP
Cyproterone Acetate Impurity F
Cyproterone Acetate EP Impurity F
Cyproterone Acetate 427-51-0 /Base
Cyproterone Acetate IMpurity F (Cyproterone)
Cyproterone Acetate EP Impurity F (Cyproterone)
1,2α-Methylene-6-chloro-6-17α-hydroxyprogesterone
6-Chloro-6-dehydro-17α-hydroxy-1,2α-Methyleneprogesterone
6-Chloro-17-hydroxy-1α,2α-Methylenepregna-4,6-diene-3,20-dione
Cyproterone Acetate Impurity 6(Cyproterone Acetate EP Impurity F)
6-chlor-delta(sup6)-1,2-alpha-methylen-17-alpha-hydroxyprogesteron
4,6-PREGNADIEN-6-CHLORO-1-ALPHA, 2-ALPHA-METHYLENE-17-OL-3,20-DIONE
(1β,2β)-6-Chloro-1,2-dihydro-17-hydroxy-3'H-cyclopropa[1,2]pregna-1,4
3’h-cyclopropa(1,2)pregna-1,4,6-triene-3,20-dione,6-chloro-1-beta,2-beta-dihyd
6-Chloro-1β,2β-dihydro-17-hydroxy-3'H-cyclopropa[1,2]pregna-4,6-diene-3,20-dione
6-chloro-1b,2b-dihydro-17-hydroxy-3'h-cyclopropa(1,2)pregna-1,4,6-triene-3,20-dione
3'H-Cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione, 6-chloro-1,2-dihydro-17-hydroxy-, (1β,2β)-
[Molecular Formula]

C22H27ClO3
[MDL Number]

MFCD00869226
[MOL File]

2098-66-0.mol
[Molecular Weight]

374.9
Chemical PropertiesBack Directory
[Melting point ]

208-210°C
[Boiling point ]

521.0±50.0 °C(Predicted)
[density ]

1.29±0.1 g/cm3(Predicted)
[storage temp. ]

Refrigerator
[solubility ]

Chloroform (Slightly), Methanol (Slightly)
[form ]

Solid
[pka]

12.86±0.70(Predicted)
[color ]

Off-White to Yellow
Hazard InformationBack Directory
[Chemical Properties]

White Solid
[Uses]

An antiandrogen, suppresses Testosterone and its metabolites. Derivatives of Cyproterone are administered to patients suffering from hypersexuality and to help facilitate the sexual transformation of male-to-female transsexuals.
[Uses]

insecticide
[Definition]

ChEBI: Cyproterone is a 20-oxo steroid, a 17alpha-hydroxy steroid, a chlorinated steroid, a 3-oxo-Delta(4) steroid and a tertiary alpha-hydroxy ketone. It has a role as an androgen antagonist. It derives from a hydride of a pregnane.
[World Health Organization (WHO)]

Cyproterone was introduced in the late sixties. It is an orallyactive anti-androgen with competitive inhibitory effects on androgen-sensitive target organs. It also has anti-gonadotropic and progestative properties. In 1995 the drug was found to have a hepatotoxic effect.
[Synthesis]

Cyproterone, 6-chloro-17|á-hydroxy-1|á,2|á-methylenpregna-4,6-dien-3,20- dione acetate (29.2.14), is made from 17|á-hydroxyprogesterone acetate (28.3.36). Dehydrating this using chloranyl (tetrachloro-p-benzoquinone) results in formation of an additional double bond at position C6¨CC7 (29.2.8), and subsequent dehydration using selenium dioxide to form the corresponding divinyl ketone, 17|á-acetoxy-1,4,6-pregnatrien- 3,20-dione (29.2.9). Reacting this with diazomethane results in a 1,3-dipolar addition reaction at C1¨CC2 of the double bond of the steroid system, which forms a derivative of dihydropyrazole (29.2.10). This compound cleaves when reacted with chloric acid, releasing nitrogen molecules and forming a cyclopropane derivative (29.1.11). Next, the double bond at C6¨CC7 is selectively oxidized by benzoyl peroxide, and the resulting epoxide (29.2.12) undergoes a reaction with hydrochloric acid in acetic acid, resulting in the formation of chlorine and its subsequent dehydration, and a simultaneous opening of the cyclopropane ring, forming the compound (29.2.13). Heating this in collidine results in intramolecular alkylation, causing cyclization into a cyclopropane ring, which forms cyproterone (29.2.14).

Synthesis_2098-66-0

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