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ChemicalBook--->CAS DataBase List--->2095486-67-0

2095486-67-0

2095486-67-0 Structure

2095486-67-0 Structure
IdentificationBack Directory
[Name]

eIF4A3 inhibitor 53a
[CAS]

2095486-67-0
[Synonyms]

eIF4A3-IN-1
eIF4A3 inhibitor 53a
eIF4A3-IN-1 (compound 53a)
Benzonitrile, 3-[4-[[(3S)-4-(4-bromobenzoyl)-3-(4-chlorophenyl)-1-piperazinyl]carbonyl]-5-methyl-1H-pyrazol-1-yl]-
[Molecular Formula]

C29H23BrClN5O2
[MDL Number]

MFCD32174248
[MOL File]

2095486-67-0.mol
[Molecular Weight]

588.88
Chemical PropertiesBack Directory
[Boiling point ]

769.3±60.0 °C(Predicted)
[density ]

1.45±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
[form ]

Solid
[pka]

-1.02±0.12(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

eIF4A3-IN-1 (compound 53a) is a selective eukaryotic initiation factor 4A3 (eIF4A3) inhibitor (IC50=0.26 μM; Kd=0.043 μM), which binds to a non-ATP binding site of eIF4A3 and shows significant cellular nonsense-mediated RNA decay (NMD) inhibition at 10 and 3 μM and can be as a probe for further study of eIF4A3, the exon junction complex (EJC), and NMD[1].
[References]

[1] Ito M, et al. Discovery of Novel 1,4-Diacylpiperazines as Selective and Cell-Active eIF4A3 Inhibitors. J Med Chem. 2017 Apr 27;60(8):3335-3351. DOI:10.1021/acs.jmedchem.6b01904
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