| Identification | Back Directory | [Name]
Thalidomide-NH-C3-NH-Boc | [CAS]
2093386-36-6 | [Synonyms]
Thalidomide-NH-C3-NH-Boc
Thalidomide-4-NH-C3-NH-Boc
Thalidomide-NH-(CH2)3-NH-Boc
tert-Butyl [3-[[2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl]amino]ethyl]carbamate
Carbamic acid, N-[3-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]propyl]-, 1,1-dimethylethyl ester | [Molecular Formula]
C21H26N4O6 | [MOL File]
2093386-36-6.mol | [Molecular Weight]
430.45 |
| Hazard Information | Back Directory | [Uses]
Thalidomide-NH-(CH2)3-NH-Boc is a Boc-modified Thalidomide (HY-14658), which acts as a Cereblon ligand to recruit CRBN protein. The Boc protecting group at the end of Thalidomide-NH-(CH2)3-NH-Boc can be removed under acidic conditions to participate in the synthesis of PROTAC molecules. Thalidomide-NH-(CH2)3-NH-Boc is a key intermediate in the synthesis of CRBN-based designed PROTAC molecules targeting 11β-substituted estradiol. | [IC 50]
Cereblon | [References]
[1] Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512(7512):49-53.??[Content Brief] DOI:10.1038/nature13527 |
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