| Identification | Back Directory | [Name]
N-(4-chlorophenyl)-4-hydroxy-3-(4-(4-(trifluoromethoxy)phenyl)piperazin-1-yl)butanamide | [CAS]
2086257-77-2 | [Synonyms]
VBIT-4
N-(4-chlorophenyl)-4-hydroxy-3-(4-(4-(trifluoromethoxy)phenyl)piperazin-1-yl)butanamide | [EINECS(EC#)]
829-870-7 | [Molecular Formula]
C21H23ClF3N3O3 | [MDL Number]
MFCD32663268 | [MOL File]
2086257-77-2.mol | [Molecular Weight]
457.874 |
| Hazard Information | Back Directory | [Description]
This product was discontinued for commercial reason. | [Uses]
VBIT-4 is an inhibitor of voltage-dependent anion channel 1 (VDAC1) oligomerization with a binding affinity (Kd) of 17 μM. VBIT-4, as an apoptosis inhibitor, can be used for therapeutic purposes in apoptosis-associated disorders, such as neurodegenerative and cardiovascular diseases[1]. | [References]
[1] Ben-Hail D, et al. Novel Compounds Targeting the Mitochondrial Protein VDAC1 Inhibit Apoptosis and Protect against Mitochondrial Dysfunction. J Biol Chem. 2016 Nov 25;291(48):24986-25003. DOI:10.1074/jbc.M116.744284 |
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| Company Name: |
InvivoChem Gold
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| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
| Company Name: |
Henan Alpha Chemical Co., Ltd.
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| Tel: |
0371-55055611 18137792234 |
| Website: |
http://m.approvedhomemanagement.com/ShowSupplierProductsList31206/0.htm |
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