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ChemicalBook--->CAS DataBase List--->2076-91-7

2076-91-7

2076-91-7 Structure

2076-91-7 Structure
IdentificationBack Directory
[Name]

NSC 55712
[CAS]

2076-91-7
[Synonyms]

R 55
NSC 55712
TPT-260 2HCl
TPT-260 , NSC55712
TPT-260 2HCl(NSC55712)
TPT-260 (hydrochloride)
TPU-260 Dihydrochloride
NSC55712 Dihydrochloride
TPT-260 (Dihydrochloride)
TPT-260 Dihydrochloride, >=98%
TPT-260 (Dihydrochloride), NSC55712
thiene-2,5-diyldimethanediyl dicarbamimidothioate
THIOPHENE-2,5-DIYLBIS(METHYLENE) DICARBAMIMIDOTHIOATE.2HCL
Thiophene-2,5-diylbis(methylene) dicarbamimidothioate dihydrochloride
Carbamimidothioic acid 2,5-thiophenediylbis(methylene) ester dihydrochloride
Carbamimidothioic acid,C,C'-[2,5-thiophenediylbis(methylene)] ester, hydrochloride (1:2)
[({5-[(carbamimidoylsulfanyl)methyl]thiophen-2-yl}methyl)sulfanyl]methanimidamide dihydrochloride
NSC55712; TPT260 DIHYDROCHLORIDE; TPT 260 DIHYDROCHLORIDE; TPU-260 DIHYDROCHLORIDE;NSC-55712;NSC 55712
NSC 55712 Carbamimidothioic acid 2,5-thiophenediylbis(methylene) ester dihydrochloride
[Molecular Formula]

C8H14Cl2N4S3
[MDL Number]

MFCD25976641
[MOL File]

2076-91-7.mol
[Molecular Weight]

333.325
Chemical PropertiesBack Directory
[Melting point ]

210℃ (Decomposition)
[storage temp. ]

Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
[solubility ]

DMSO:62.5(Max Conc. mg/mL);240.02(Max Conc. mM)
[form ]

A crystalline solid
[color ]

Light yellow to yellow
[Water Solubility ]

water: 50mg/mL
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H315-H319
[Precautionary statements ]

P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
Hazard InformationBack Directory
[Uses]

Retromers are multiprotein complexes responsible for trafficking cargo out of endosomes. This is an important function that, in the case of amyloid-precursor protein (APP), is neuroprotective by preventing APP from being cleaved into Alzheimer’s disease-inducing fragments via the endosome. TPT-260 is a thiophene thiourea derivative that acts as a chaperone to stabilize the retromer complex against thermal denaturation (Kd = ~5 μM). In cultured hippocampal neurons, TPT-260 dose-dependently increases the level of retromer proteins, redirects APP from the endosome, and reduces the formation of pathogenic APP.[Cayman Chemical]
[Biological Activity]

Cell permeable: yes''Primary Target
vacuolar protein sorting (Vps) proteins''Reversible: yes
[storage]

Store at -20°C
Spectrum DetailBack Directory
[Spectrum Detail]

NSC 55712(2076-91-7)1HNMR
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