| Identification | Back Directory | [Name]
IDO-IN-3 | [CAS]
2070018-30-1 | [Synonyms]
IDO-IN-3
IDO inhibitor 3
1,2,5-Oxadiazole-3-carboximidamide, 4-[(2-aminoethyl)amino]-N'-(3-bromo-4-fluorophenyl)-N-hydroxy- | [Molecular Formula]
C11H12BrFN6O2 | [MOL File]
2070018-30-1.mol | [Molecular Weight]
359.15 |
| Chemical Properties | Back Directory | [Boiling point ]
570.8±60.0 °C(Predicted) | [density ]
1.86±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Ethanol: 1 mg/ml | [form ]
A crystalline solid | [pka]
7?+-.0.69(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
IDO-IN-3 is an inhibitor of indoleamine-2,3-dioxygenase 1 (IDO1; IC50s = 290 and 98 nM for the human recombinant enzyme in a cell-free assay and in HeLa cells, respectively). | [Uses]
IDO-IN-3 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor with an IC50 of 290 nM. | [IC 50]
IDO: 290 nM (IC50); IDO: 98 nM (IC50, in HeLa cell) | [storage]
Store at -20°C | [References]
[1] Yue EW, et al. INCB24360 (Epacadostat), a Highly Potent and Selective Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitor for Immuno-oncology. ACS Med Chem Lett. 2017 Mar 6;8(5):486-491. DOI:10.1021/acsmedchemlett.6b00391 |
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