| Identification | Back Directory | [Name]
BOC-TRANS-4-FLUORO-L-PROLINE METHYL ESTER | [CAS]
203866-18-6 | [Synonyms]
BOC-TRANS-4-FLUORO-L-PROLINE METHYL ESTER
(4R)-1-BOC-4-FLUORO-L-PROLINE METHYL ESTER
N-Boc-tran-4-Fluoro-L-proline Methyl ester
1-Boc-Trans-4-fluoro-L-proline Methyl ester
N-Boc-trans-4-fluoro-L-proline methyl ester
N-T-BOC-TRANS-4-FLUORO-L-PROLINE METHYL ESTER
N-Boc-trans-4-fluoro-L-proline methyl ester 97%
(2S,4R)-N-Boc-trans-4-fluoro-L-proline methyl ester
BOC-TRANS-4-FLUORO-L-PROLINE METHYL ESTER USP/EP/BP
Methyl (2S,4R)-1-Boc-4-fluoropyrrolidine-2-carboxylate
METHYL N-(TERT-BUTOXYCARBONYL)-(2S, 4R)-4-FLUOROPROLINATE
-1-tert-Butyl 2-methyl 4-fluoropyrrolidine-1,2-dicarboxylate
(2S,4R)-1-tert-Butyl 2-Methyl 4-fluoropyrrolidine-1,2-dicarboxylate
1-tert-butyl 2-methyl (2S,4R)-4-fluoropyrrolidine-1,2-dicarboxylate
1-tert-Butyl 2-methyl (2S,4R)-4-fluoro-1,2-pyrrolidinedicarboxylate
1-O-tert-butyl 2-O-methyl (2S,4R)-4-fluoropyrrolidine-1,2-dicarboxylate
(2S,4R)-4-Fluoro-tert-butyl-1,2-pyrrolidinedicarboxylic Acid 2-Methyl Ester
(2S,4R)-4-Fluoro-1,2-pyrrolidinedicarboxylic acid 1-(tert-butyl) 2-methyl ester
(2S,4R)-4-Fluoro-tert-butyl-1,2-pyrrolidinedicarboxylic A
cid 2-Methyl Ester,99%e.e.
(2S,4R)-4-fluoropyrrolidine-1,2-dicarboxylic acid O1-tert-butyl ester O2-methyl ester
1,2-Pyrrolidinedicarboxylic acid, 4-fluoro-, 1-(1,1-dimethylethyl) 2-methyl ester, (2S,4R)- | [Molecular Formula]
C11H18FNO4 | [MDL Number]
MFCD07367993 | [MOL File]
203866-18-6.mol | [Molecular Weight]
247.26 |
| Chemical Properties | Back Directory | [Melting point ]
36-39°C | [density ]
1.16 | [Fp ]
110 °C | [storage temp. ]
2-8°C | [form ]
powder | [Appearance]
Colorless to off-white <36°C Solid,>39°C Liquid | [Optical Rotation]
[α]22/D -80.0°, c = 1 in methanol | [Water Solubility ]
Insoluble in water. | [InChI]
InChI=1S/C11H18FNO4/c1-11(2,3)17-10(15)13-6-7(12)5-8(13)9(14)16-4/h7-8H,5-6H2,1-4H3/t7-,8+/m1/s1 | [InChIKey]
METPQQHVRNLTRX-SFYZADRCSA-N | [SMILES]
N1(C(OC(C)(C)C)=O)C[C@H](F)C[C@H]1C(OC)=O |
| Hazard Information | Back Directory | [Uses]
N-Boc-trans-4-fluoro-L-proline methyl ester is used to prepare (S)-2-[N-(N'-benzyl-(S)-4-fluoro-L-prolyl)amino]benzophenone by reacting with of 2-aminobenzophenone in the presence of potassium tert -butoxide. | [Synthesis]
GENERAL STEPS: (2S,4R)-1-[(tert-butoxy)carbonyl]-4-fluoropyrrolidine-2-carboxylic acid (2 g, 8.57 mmol), potassium carbonate (5.9 g, 42.69 mmol), and THF (80 mL) were mixed, and methyl iodide (6.1 g, 42.98 mmol) was added, and the reaction was stirred for 12 hours at room temperature. After completion of the reaction, the solid was removed by filtration and the filtrate was concentrated under reduced pressure. The residue was purified by rapid chromatography on silica gel with EtOAc/petroleum ether (1:5) as eluent to afford N-BOC-trans-4-fluoro-L-proline methyl ester (800 mg, 38% yield) as a colorless oil. | [References]
[1] Patent: WO2015/52264, 2015, A1. Location in patent: Paragraph 0521; 0522; 01714; 01715 |
|
|