| Identification | Back Directory | [Name]
PHENAMIL | [CAS]
2038-35-9 | [Synonyms]
PHENAMIL
phenylamil
phenamil methanesulfonate salt
Phenamil methanesulfonate (free base)
3,5-diamino-N-[amino(anilino)methylene]-6-chloro-pyrazinamide
3,5-DIAMINO-6-CHLORO-N-[IMINO(PHENYLAMINO)METHYL]-PYRAZINECAR-BOXAMIDE
3,5-Diamino-6-chloro-N-[imino(phenylamino)methyl]pyrazine-2-carboxamide
3,5-diamino-N-[amino(anilino)methylidene]-6-chloropyrazine-2-carboxamide
2-Pyrazinecarboxamide, 3,5-diamino-6-chloro-N-[imino(phenylamino)methyl]-
3,5-bis(azanyl)-N-[azanyl-(phenylamino)methylidene]-6-chloro-pyrazine-2-carboxamide
3,5-diamino-6-chloro-n-[imino(phenylamino)methyl]pyrazinecarboxamide methanesulfonate salt | [Molecular Formula]
C12H12ClN7O | [MDL Number]
MFCD00210211 | [MOL File]
2038-35-9.mol | [Molecular Weight]
305.72 |
| Hazard Information | Back Directory | [Uses]
Phenamil Methanesulfonate Salt induced differentiation and peroxisome proliferator-activator receptor γ expression through ETS variant 4 in mouse preadipocyte | [Definition]
ChEBI: Phenylamil is a member of pyrazines and a member of guanidines. | [Enzyme inhibitor]
This amiloride derivative (FW = 306.73 g/mol; CAS 2038-35-9), also known as 3,5-diamino-6-chloro-N-[imino(phenylamino)methyl]pyrazine carboxamide, irreversibly inhibits amiloride-sensitive Na+ channels. It is often supplied commercially as the methanesulfonate salt. Na+ channel blockers, such as phenamil and benzamil, are be alsoing explored as a way to counteract the hyperabsorption of NaCl in cystic fibrosis airways. Target(s): diamine oxidase; Na+ channels; and Na+ -driven flagellar motility. |
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