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ChemicalBook--->CAS DataBase List--->202917-18-8

202917-18-8

202917-18-8 Structure

202917-18-8 Structure
IdentificationBack Directory
[Name]

3-Pyridinemethanol, 4-(4-fluoro-2-hydroxyphenyl)-a-methyl-2,6-bis(1-methylethyl)-5-propyl-, (aR,4S)-rel- (9CI)
[CAS]

202917-18-8
[Synonyms]

Glucagon receptor antagonist 2
glucagon receptor antagonists-2
(alphaR,4S)-4-(4-Fluoro-2-hydroxyphenyl)-alpha-methyl-2,6-bis(1-methylethyl)-5-propyl-3-pyridinemethanol
3-Pyridinemethanol, 4-(4-fluoro-2-hydroxyphenyl)-a-methyl-2,6-bis(1-methylethyl)-5-propyl-, (aR,4S)-rel- (9CI)
3-Pyridinemethanol, 4-(4-fluoro-2-hydroxyphenyl)-α-methyl-2,6-bis(1-methylethyl)-5-propyl-, (αR,4S)-rel- (9CI)
3-PyridineMethanol, 4-(4-fluoro-2-hydroxyphenyl)-.alpha.-Methyl-2,6-bis(1-Methylethyl)-5-propyl-, (.alpha.R,4S)-rel- (9CI)
3-Pyridinemethanol, 4-(4-fluoro-2-hydroxyphenyl)-a-methyl-2,6-bis(1-methylethyl)-5-propyl-, (aR,4S)-rel- (9CI) ISO 9001:2015 REACH
[Molecular Formula]

C22H30FNO2
[MOL File]

202917-18-8.mol
[Molecular Weight]

359.48
Chemical PropertiesBack Directory
[Boiling point ]

469.6±45.0 °C(Predicted)
[density ]

1.085
[storage temp. ]

Store at -20°C
[solubility ]

DMSO : 16.67 mg/mL (46.37 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
[form ]

Powder
[pka]

6.96±0.35(Predicted)
[color ]

White to off-white
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P305+P351+P338
Hazard InformationBack Directory
[Uses]

Glucagon receptor antagonist-2 is a highly potent glucagon receptor antagonist.
[References]

[1] Ladouceur, Gaetan H. et al. Integration of optimized substituent patterns to produce highly potent 4-aryl-pyridine glucagon receptor antagonists. Bioorganic & Medicinal Chemistry Letters (2002), 12(23), 3421-3424. DOI:10.1016/s0960-894x(02)00736-9
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