| Identification | Back Directory | [Name]
M-3M3FBS | [CAS]
200933-14-8 | [Synonyms]
M-3M3FBS
Phospholipase C Activator,
2,4,6-TRIMETHYL-N-(3-(TRIFLUOROMETHYL)PH
N-(3-TRIFLUOROMETHYLPHENYL)-2,4,6-TRIMETHYLBENZENESULFONAMIDE
2,4,6-TRIMETHYL-N-[3-(TRIFLUOROMETHYL)PHENYL]BENZENESULFONAMIDE
2,4,6-TRIMETHYL-N-(M-3-TRIFLUOROMETHYLPHENYL)BENZENESULFONAMIDE
Phospholipase C Activator, m-3M3FBS - CAS 200933-14-8 - Calbiochem
Benzenesulfonamide, 2,4,6-trimethyl-N-[3-(trifluoromethyl)phenyl]-
calcium,superoxide,cells,THP-1,phosphate,m 3M3FBS,m-3M3FBS,Apoptosis,Inhibitor,m3M3FBS,Phospholipase,leukemic,U937,inositol,inhibit,neutrophils,m-3M-3FBS | [Molecular Formula]
C16H16F3NO2S | [MDL Number]
MFCD00095824 | [MOL File]
200933-14-8.mol | [Molecular Weight]
343.36 |
| Chemical Properties | Back Directory | [Melting point ]
114-114.8 °C(lit.)
| [Boiling point ]
420.0±55.0 °C(Predicted) | [density ]
1.316±0.06 g/cm3(Predicted) | [storage temp. ]
Store at RT | [solubility ]
DMSO: 92 mg/mL
| [form ]
solid
| [pka]
7.82±0.10(Predicted) | [color ]
white
| [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
| Hazard Information | Back Directory | [Description]
m-3M3FBS (200933-14-8) is an activator of phospholipase C (PLC). Stimulates superoxide generation, Ca2+ release and inositol phosphate release in a variety of cell types.1?Inhibits growth of U937 and THP-1 cells.2 m-3M3FBS also affects calcium homeostasis independently of PLC activation.3 | [Uses]
m-3M3FBS has been used for MAP kinase assay in 293T cells. It has also been used for intracellular calcium analysis1. Furthermore, it has been used (at a conc. of 1 μM) as a PLC activator for sensitizing TRPA1 in HEK293t cells2. | [Uses]
m-3M3FBS is used in biological studies as phospholipase C activator m-3M3FBS effects on Ca2+ homeostasis independently of phospholipase C activation. | [Definition]
ChEBI: 2,4,6-trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide is a sulfonamide. | [Biological Activity]
Activator of phospholipase C (PLC). Stimulates superoxide generation, Ca 2+ release and inositol phosphate formation in a variety of cell types. | [Biochem/physiol Actions]
First known direct activator of phospholipase C (activates β2, β3, γ1, γ2, δ1 isoforms). | [storage]
Store at RT | [References]
1) Bae?et al. (2003),?Identification of a compound that directly stimulates phospholipase C activity; Mol. Pharmacol.,?63?1043
2) Lee?et al. (2005),?The novel phospholipase C activator, m-3M3FBS, induces monocytic leukemia cell apoptosis; Cancer Lett.,?222?227
3) Krjukova?et al. (2004),?Phospholipase C activator m-3M3FBS affects Ca2+ homeostasis independently of phospholipase C activation; Br. J. Pharmacol.,?143?3 |
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