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ChemicalBook--->CAS DataBase List--->199864-86-3

199864-86-3

199864-86-3 Structure

199864-86-3 Structure
IdentificationBack Directory
[Name]

2-PyriMidinaMine, 4-(4-fluoro-1-naphthalenyl)-6-(1-Methylethyl)-, Monohydrochloride
[CAS]

199864-86-3
[Synonyms]

MT 500 Hydrochloride
RS 127445 hydrochloride NEW
4-(4-Fluoro-1-naphthyl)-6-isopropylpyriMidin-2-aMine
2-Amino-4-(4-fluoronaphth-1-yl)-6-isopropylpyrimidine hydrochloride
2-AMino-4-(4-fluoronaphth-1-yl)-6-isopropylpyriMidine Monohydrochloride
4-(4-Fluoro-1-naphthalenyl)-6-(1-methylethyl)-2-pyrimidinamine monohydrochloride
2-PyriMidinaMine, 4-(4-fluoro-1-naphthalenyl)-6-(1-Methylethyl)-, Monohydrochloride
[Molecular Formula]

C17H17ClFN3
[MDL Number]

MFCD11112196
[MOL File]

199864-86-3.mol
[Molecular Weight]

317.788
Chemical PropertiesBack Directory
[Melting point ]

158 °C
[storage temp. ]

2-8°C
[solubility ]

DMSO: ≥20mg/mL
[form ]

powder
[color ]

white to tan
Safety DataBack Directory
[Hazard Codes ]

T
[Risk Statements ]

25-36
[Safety Statements ]

26-45
[RIDADR ]

UN 2811 6.1 / PGIII
[WGK Germany ]

3
[HS Code ]

2933.59.5300
Hazard InformationBack Directory
[Uses]

RS-127445 is a selective; high affinity; orally bioavailable serotonin 5-HT2B receptor antagonist. RS-127445 was found to have nanomolar affinity for the 5-HT2B receptor (pKi=9.5) and 1,000 fold selec tivity for this receptor as compared to numerous other receptor and ion channel binding sites.
[Biological Activity]

RS-127445 is a selective; high affinity; orally bioavailable serotonin 5-HT2B receptor antagonist. RS-127445 was found to have nanomolar affinity for the 5-HT2B receptor (pKi=9.5) and 1,000 fold selectivity for this receptor as compared to numerous other receptor and ion channel binding sites.
[in vivo]

In rats, the fraction of RS-127445 that is bioavailable via the oral or intraperitoneal routes is 14 and 60% respectively. Intraperitoneal administration of RS-127445 (5 mg/kg) produced plasma concentrations predicted to fully saturate accessible 5-HT2B receptors for at least 4 h.RS-127445 (5 mg/kg) is administered to rats by oral, intraperitoneal and intravenous routes. Peak plasma concentrations are rapidly achieved with the highest concentrations being found at the first time-point measured following intravenous and intraperitonael administration (0.08 h) and by 0.25 h following dosing by the oral route of administration. RS-127445 is cleared from plasma with an estimated terminal elimination half-life of approximately 1.7 h. The bioavailability of RS-127445, when administered by the oral and intraperitoneal routes is approximately 14 and 62% of that obtained by intravenous administration. Approximately 60% of an intraperitoneal dose and 14% of the oral dose of RS-127445 (5 mg/kg) is bioavailable[1]. RS-127445 (1-30 mg/kg), dose-dependently reduces faecal output, reaching significance at 10 and 30 mg/kg (n=6-11). In blood and brain, >98% of RS-127445 is protein-bound[2].

[IC 50]

sPLA2: 5.5 (pKi); 5-HT3 Receptor: <6 (pKi); 5-HT5 Receptor: <6 (pKi); 5-HT6 Receptor: <6 (pKi); 5-HT2A Receptor: 6.3 (pKi); 5-HT2C Receptor: 6.4 (pKi); 5-HT2B Receptor: 9.5 (pKi)
[storage]

Desiccate at +4°C
Spectrum DetailBack Directory
[Spectrum Detail]

2-PyriMidinaMine, 4-(4-fluoro-1-naphthalenyl)-6-(1-Methylethyl)-, Monohydrochloride(199864-86-3)1HNMR
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