| Identification | Back Directory | [Name]
Furanodiene | [CAS]
19912-61-9 | [Synonyms]
Furanodiene
Furanodiene ISO 9001：2015 REACH
3,6,10-Trimethyl-4,7,8,11-tetrahydro-cyclodeca[B]furan
(5E)-3,6,10-Trimethyl-4,7,8,11-tetrahydrocyclodeca[B]furan
(5E,9Z)-4,7,8,11-Tetrahydro-3,6,10-trimethylcyclodeca[b]furan
Cyclodeca[B]furan, 4,7,8,11-tetrahydro-3,6,10-trimethyl-, (5E)-
Cyclodeca[b]furan, 4,7,8,11-tetrahydro-3,6,10-trimethyl-, (5E,9Z)-
Inchi=1/C15H20o/C1-11-5-4-6-12(2)9-15-14(8-7-11)13(3)10-16-15/H6-7,10H,4-5,8-9H2,1-3H3/B11-7+,12-6 | [Molecular Formula]
C15H20O | [MDL Number]
MFCD30479113 | [MOL File]
19912-61-9.mol | [Molecular Weight]
216.32 |
| Chemical Properties | Back Directory | [Melting point ]
74-75 °C | [Boiling point ]
309.6±11.0 °C(Predicted) | [density ]
0.945±0.06 g/cm3(Predicted) | [form ]
Solid | [color ]
Off-white to light yellow | [LogP]
5.369 (est) | [CAS DataBase Reference]
19912-61-9 |
| Hazard Information | Back Directory | [Hazard]
A poison by ingestion. | [Uses]
Furanodiene is a natural terpenoid isolated from Rhizoma Curcumae. Furanodiene plays anti-cancer effects through anti-angiogenesis and inducing ROS production, DNA strand breaks and apoptosis. Furanodiene suppresseed efflux transporter Pgp (P-glycoprotein) function and reduced Pgp protein level[1]. | [Anticancer Research]
Tested on uterine cervical (UI4) and sarcoma 180 (S180) tumors in mice, the furanodienehas a significant tumor inhibition rate dose-dependent. The furanodienewas administered intraperitoneally as liposome. The effect of furanodiene on theinhibition of cell proliferation by activation of apoptosis was not hypothesized(Song et al. 2014, Zielińska and Matkowski 2014, Polo et al. 2013). | [References]
[1] Xiao-Yu Zhu, et al. Sensitization and synergistic anti-cancer effects of Furanodiene identified in zebrafish models. Sci Rep. 2019 Mar 14;9(1):4541. DOI:10.1038/s41598-019-40866-2 |
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