| Identification | Back Directory | [Name]
11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine | [CAS]
1977-07-7 | [Synonyms]
Dechloroclozapine
Dopamine serotonin antagonist-1
11-(4-methyl-1-piperazinyl)-5H-dibenzo(b,e)(1,4)diazepine
11-(4-Methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine
5H-Dibenzo[b,e][1,4]diazepine, 11-(4-methyl-1-piperazinyl)- | [Molecular Formula]
C18H20N4 | [MDL Number]
MFCD01730958 | [MOL File]
1977-07-7.mol | [Molecular Weight]
292.38 |
| Chemical Properties | Back Directory | [Boiling point ]
457.5±55.0 °C(Predicted) | [density ]
1.22±0.1 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
DMSO : ≥ 83.3 mg/mL (284.90 mM) | [form ]
solid | [pka]
7.82±0.20(Predicted) | [color ]
Yellow |
| Hazard Information | Back Directory | [Biological Activity]
Deschloroclozapine is a potent, high-affinity, selective, metabolically stable agonist of muscarinic-based DREADDs. | [in vitro]
Deschloroclozapine has greater potencies for DREADDs than previous agonists in vitro. Deschloroclozapine is a potent agonist for hM 3 Dq with an EC 50 =0.13 nM. Deschloroclozapine is also a potent agonist for hM 4 Di with an EC 50 =0.081 nM.
Deschloroclozapine is a potent and selective agonist for hM 3 Dq and hM 4 Di, it does not display significant agonistic activity for any of the 318 tests wild-type GPCRs at <10 nM. b> | [target]
Ki: 6.3 nM (hM 3 Dq), 4.2 nM (hM 4 Di) | [storage]
Store at -20°C |
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