| Identification | Back Directory | [Name]
GAP 26 | [CAS]
197250-15-0 | [Synonyms]
GAP 26
GAP-26; GAP26
43Gap 26, Connexin Mimetic
M.W. 1550.78 C70H107N19O19S
Val-Cys-Tyr-Asp-Lys-Ser-Phe-Pro-Ile-Ser-His-Val-Arg
GAP 26/Connexin 43 (63-75) (human, bovine, mouse, rat), Gap Junction α-1 Protein (63-75)
L-Arginine, L-valyl-L-cysteinyl-L-tyrosyl-L-α-aspartyl-L-lysyl-L-seryl-L-phenylalanyl-L-prolyl-L-isoleucyl-L-seryl-L-histidyl-L-valyl- | [Molecular Formula]
C70H107N19O19S | [MDL Number]
MFCD06411601 | [MOL File]
197250-15-0.mol | [Molecular Weight]
1550.78 |
| Chemical Properties | Back Directory | [density ]
1.47±0.1 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [solubility ]
insoluble in EtOH; ≥155.1 mg/mL in H2O with ultrasonic; ≥77.55 mg/mL in DMSO with gentle warming and ultrasonic | [form ]
solid | [pka]
3.31±0.10(Predicted) | [color ]
White to off-white | [Water Solubility ]
Soluble to 2 mg/ml in water | [Sequence]
H-Val-Cys-Tyr-Asp-Lys-Ser-Phe-Pro-Ile-Ser-His-Val-Arg-OH |
| Hazard Information | Back Directory | [Uses]
Gap26 is a connexin (Cx) mimetic peptide and a gap junction blocker. | [Biological Activity]
Gap 26 is a 13-mer peptide derived from the first extracellular loop I sequence of connexin-43 (h/m/r Cx43 aa64-76 or aa63-75 after Met1 removal). Gap 26 is widely employed to block and probe Cx43-mediated gap junctional signaling in cultures (20-160 μM) and in animals in vivo. | [storage]
Desiccate at -20°C |
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