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ChemicalBook--->CAS DataBase List--->1970972-74-7

1970972-74-7

1970972-74-7 Structure

1970972-74-7 Structure
IdentificationBack Directory
[Name]

Danicamtiv
[CAS]

1970972-74-7
[Synonyms]

MYK-491
SAR 440181
Danicamtiv
Danicamtiv (MYK-491)
Inhibitor,allosteric,cardiac,function,inhibit,Myosin,Danicamtiv,acto-myosin,inotropic,systolic,MYK 491,MYK491
1-Piperidinecarboxamide, 4-[(1R)-1-[[3-(difluoromethyl)-1-methyl-1H-pyrazol-4-yl]sulfonyl]-1-fluoroethyl]-N-3-isoxazolyl-
[Molecular Formula]

C16H20F3N5O4S
[MOL File]

1970972-74-7.mol
[Molecular Weight]

435.42
Chemical PropertiesBack Directory
[Boiling point ]

699.1±55.0 °C(Predicted)
[density ]

1.57±0.1 g/cm3(Predicted)
[solubility ]

DMSO:50.0(Max Conc. mg/mL);114.83(Max Conc. mM)
[form ]

A solid
[pka]

13.32±0.40(Predicted)
[color ]

Off-white to light yellow
Hazard InformationBack Directory
[Uses]

Danicamtiv (MYK-491), an inotropic agent, is a selective allosteric activator of cardiac myosin. Danicamtiv increases cardiac systolic function and preserves mechanical efficiency[1].
[in vivo]

Danicamtiv selectively enhances cardiac actomyosin activity, the molecular force‐generating unit of the sarcomere, prolonging contraction while preserving actin–myosin detachment, allowing relaxation, and without impacting Ca2+ homeostasis[2].

[References]

[1] Sarah Fernandes, et al. Abstract 15707: MYK-491, a Novel Small-Molecule Cardiac Myosin Activator Increases Cardiac Systolic Function and Preserves Mechanical Efficiency: Pre-Clinical in vivo and in vitro Evidence. Circulation. 2019;140:A15707
[2] Voors AA, et al. Effects of danicamtiv, a novel cardiac myosin activator, in heart failure with reduced ejection fraction: experimental data and clinical results from a phase 2a trial. Eur J Heart Fail. 2020;22(9):1649-1658. DOI:10.1002/ejhf.1933
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