| Identification | Back Directory | [Name]
LDH-IN-1 | [CAS]
1964515-43-2 | [Synonyms]
LDH-IN-1
LDH inhibitor 1
Lactate Dehydrogenase,inhibit,LDH,LDH IN 1,Inhibitor,LDHIN1
4-Thiazolecarboxylic acid, 2-[4-[[4-(aminosulfonyl)phenyl]methyl]-3-[1,1'-biphenyl]-3-yl-5-(cyclopropylmethyl)-1H-pyrazol-1-yl]- | [Molecular Formula]
C30H26N4O4S2 | [MDL Number]
MFCD31657379 | [MOL File]
1964515-43-2.mol | [Molecular Weight]
570.68 |
| Chemical Properties | Back Directory | [Boiling point ]
837.5±75.0 °C(Predicted) | [density ]
1.46±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 52 mg/mL (91.12 mM);Water : < 0.1 mg/mL (insoluble) | [form ]
Solid | [pka]
3.19±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
LDH-IN-1 is a novel pyrazole-based inhibitor of human lactate dehydrogenase (LDH) with IC50s of 32 and 27 nM for LDHA and LDHB, respectively. | [in vivo]
LDH-IN-1 shows clearance values that far exceed hepatic blood flow (HBF) in mouse species (90 mL/min/kg), with in vivo clearances of 227 mL/min/kg[1]. | [storage]
Store at -20°C | [References]
[1] Rai G, et al. Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH). J Med Chem. 2017 Nov 22;60(22):9184-9204. DOI:10.1021/acs.jmedchem.7b00941 |
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| Company Name: |
ChemCell Biomedicine Co.,Ltd.
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| Tel: |
020-13556033878 2965585218 13556033878 |
| Website: |
http://m.approvedhomemanagement.com/ShowSupplierProductsList15061/0.htm |
| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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