| Identification | Back Directory | [Name]
AVex-73 | [CAS]
195615-83-9 | [Synonyms]
AE38
AE37
CS-2603
AVex-73
Blarcamesine (Anavex-2-73)
1-(2,2-diphenyloxolan-3-yl)-N,N-dimethylmethanamine
3-Furanmethanamine, tetrahydro-N,N-dimethyl-2,2-diphenyl- | [Molecular Formula]
C19H23NO | [MDL Number]
MFCD28502178 | [MOL File]
195615-83-9.mol | [Molecular Weight]
281.39 |
| Hazard Information | Back Directory | [Uses]
Blarcamesine is an orally bioavailable Sigma-1 receptor agonist and muscarinic receptor modulator, with anticonvulsant, anti-amnesic, neuroprotective and antidepressant properties. Blarcamesine ameliorates neurologic impairments in a mouse model of Rett syndrome[1]. | [in vivo]
Blarcamesine (10 mg/kg, 30 mg/kg; p.o.; daily; for 6.5 weeks) ameliorates motor deficits in Mecp2 HET mice with chronic administration[1].
Blarcamesine ameliorates acoustic startle deficit in Mecp2 HET mice[1].
Blarcamesine reverses deficits in visual acuity in older Mecp2 HET mice using the optokinetic response[1].
Blarcamesine produces minimal effects on body weight gain in Mecp2 HET mice[1].
| Animal Model: | Female Mecp2tm1.1Bird/J HET (C57 background) mice[1] | | Dosage: | 10 mg/kg, 30 mg/kg | | Administration: | Oral administration, daily, for 6.5 weeks | | Result: | Reverse the deficits observed in the HET animals. |
| [IC 50]
Sigma 1 Receptor | [References]
[1] Walter E Kaufmann, et al. ANAVEX?2-73 (Blarcamesine), a Sigma-1 Receptor Agonist, Ameliorates Neurologic Impairments in a Mouse Model of Rett Syndrome. Pharmacol Biochem Behav . 2019 Dec;187:172796. DOI:10.1016/j.pbb.2019.172796 |
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