| Identification | Back Directory | [Name]
FmocNH-PEG12-CH2CH2COOH | [CAS]
1952360-91-6 | [Synonyms]
Fmoc-nh-peg(16)-cooh
Fmoc-nh-peg12-C2-cooh
Carboxy-PEG12-(Fmoc-amine)
(Fmoc-amino)-PEG12-C2-Carboxylic Acid
1-(9H-Fluoren-9-yl)-3-oxo-2,7,10,13,16,19,22,25,28,31,34,37,40-tridecaoxa-4-azatritetracontan-43-oic Acid
5,8,11,14,17,20,23,26,29,32,35,38-Dodecaoxa-2-azahentetracontanedioic acid, 1-(9H-fluoren-9-ylmethyl) ester | [Molecular Formula]
C42H65NO16 | [MOL File]
1952360-91-6.mol | [Molecular Weight]
839.96 |
| Chemical Properties | Back Directory | [Boiling point ]
870.4±65.0 °C(Predicted) | [density ]
1.175±0.06 g/cm3(Predicted) | [form ]
clear liquid | [pka]
4.28±0.10(Predicted) | [color ]
Colorless to Light yellow | [InChIKey]
JYNHRDJTWNEGJE-UHFFFAOYSA-N | [SMILES]
C(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(O)=O |
| Hazard Information | Back Directory | [Description]
Fmoc-N-amido-PEG12-acid is a PEG linker containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. | [Uses]
Fmoc-NH-PEG12-CH2CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [General Description]
FmocNH-PEG12-CH2CH2COOH is a PEG-based PROTAC linker. Fmoc-NH-PEG12-CH2CH2COOH can be used in the synthesis of PROTAC.
| [IC 50]
PEGs | [storage]
Keep in dark place,Inert atmosphere,Store in freezer, under -20 ℃. | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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