| Identification | Back Directory | [Name]
MAK-683 | [CAS]
1951408-58-4 | [Synonyms]
MAK-683
CPD 1111
EED inhibitor-1
MAK 683;MAK-683;MAK683
N-[(5-FLUORO-2,3-DIHYDROBENZOFURAN-4-YL)METHYL]-8-(2-METHYL-3-PYRIDYL)-[1,2,4]TRIAZOLO[4,3-C]PYRIMID
N-[(5-Fluoro-2,3-dihydro-4-benzofuranyl)methyl]-8-(2-methyl-3-pyridinyl)-1,2,4-triazolo[4,3-c]pyrimidin-5-amine
1,2,4-Triazolo[4,3-c]pyrimidin-5-amine, N-[(5-fluoro-2,3-dihydro-4-benzofuranyl)methyl]-8-(2-methyl-3-pyridinyl)- | [Molecular Formula]
C20H17FN6O | [MDL Number]
MFCD31630846 | [MOL File]
1951408-58-4.mol | [Molecular Weight]
376.39 |
| Chemical Properties | Back Directory | [density ]
1.47±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 15 mg/ml | [form ]
A solid | [pka]
2.70±0.12(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
MAK-683 is an inhibitor of trimethylation of histone 3 lysine 27 (H3K27) by polycomb repressive complex 2 (PRC2), a complex that includes embryonic ectoderm development protein (EED). MAK-683 has an IC50 value of 5.9 nM in an EED-H3K27me3 peptide competition binding assay and inhibits H3K27 trimethylation in G401 cells (IC50 = 2.6 nM). It inhibits proliferation of KARPAS422 B cell lymphoma cells with an IC50 value of 3 nM. | [Uses]
MAK-683 is a useful intermediate for the preparation of triazolopyrimidine compounds useful in the treatment of diseases or disorders mediated by EED and/or PRC2. EED inhibitor-1. |
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