| Identification | Back Directory | [Name]
N-[6-(2,6-Dichlorophenyl)-2-[[4-(diethylamino)butyl]amino]pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea | [CAS]
192705-80-9 | [Synonyms]
PD 161570
PF-1480232
PD-161570;PF-1480232
1-(tert-Butyl)-3-(6-(2,6-dichlorophenyl)-2-((4-(diethylamino)butyl)amino)pyrido[2,3-d]pyrimidi
1-Tert-butyl-3-[6-(2,6-dichloro-phenyl)-2-(4-diethylaMino-butylaMino)pyrido[2,3-d]pyriMidin-7-yl]urea
N-[6-(2,6-Dichlorophenyl)-2-[[4-(diethylamino)butyl]amino]pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea | [Molecular Formula]
C26H35Cl2N7O | [MDL Number]
MFCD16618403 | [MOL File]
192705-80-9.mol | [Molecular Weight]
532.51 |
| Chemical Properties | Back Directory | [Melting point ]
215-230?C | [density ]
1.249±0.06 g/cm3(Predicted) | [storage temp. ]
Store at RT | [solubility ]
DMSO: >10mg/mL | [form ]
powder | [pka]
9.82±0.43(Predicted) | [color ]
white to off-white |
| Hazard Information | Back Directory | [Chemical Properties]
Off-White Solid | [Uses]
A novel FGF-1 receptor tyrosine kinase inhibitor which has been shown to effectively suppress constitutive phosphorylation of the FGF-1 receptor in human ovarian carcinoma cells. | [Biological Activity]
PD-161570 is an inhibitor of human FGF-1 receptor tyrosine kinase. | [IC 50]
FGFR1: 39.9 nM (IC50); FGFR1: 42 nM (Ki); FGFR1 autophosphorylation: 622 nM (IC50); PDGFRβ: 262 nM (IC50); PDGFR: 310 nM (IC50); EGFR: 240 nM (IC50); c-Src: 44 nM (IC50); TGF-β Receptor | [storage]
Store at -20°C |
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