| Identification | Back Directory | [Name]
METHYL 6-AMINOCAPROATE HYDROCHLORIDE | [CAS]
1926-80-3 | [Synonyms]
TIMTEC-BB SBB003739
METHYL 6-AMINOCAPROATE
METHYL 6-AMINOHEXANOATE HCL
6-aminohexanoate hydrochloride
Methyl 6-aMinocapte hydrochloride
METHYL 6-AMINOCAPROATE HYDROCHLORIDE
Methyl 6-aminocappoate hydrochloride
METHYL 6-AMINOHEXANOATE HYDROCHLORIDE
6-Aminocaproic acid methyl ester hydrochloride
6-Aminohexanoic acid methyl ester hydrochloride
Methyl 6-aMinohexanoate hydrochloride >=99.0% (AT)
6-Aminohexanoic acid methyl ester monohydrochloride
Methyl ester- 6-aMino- Hexanoic acid, hydrochloride
methyl ester- 6-amino- Hexanoic acid, hydrochloride (1:1)
Hexanoic acid, 6-amino-, methyl ester, hydrochloride (1:1)
Methyl 6-aminohexanoate hydrochloride,Methyl 6-aminocaproate hydrochloride | [Molecular Formula]
C7H16ClNO2 | [MDL Number]
MFCD00035455 | [MOL File]
1926-80-3.mol | [Molecular Weight]
181.66 |
| Chemical Properties | Back Directory | [Melting point ]
117-124 °C | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
White to Off-White | [BRN ]
3687692 |
| Hazard Information | Back Directory | [Uses]
Methyl 6-aminohexanoate is used as a reagent to synthesize straight chain hydroxamates, compounds that act as inhibitors of Human Histone Deacetylase (HDAC) that have the potential to treat cancer. Methyl 6-aminohexanoate is also sometimes used as a spacer unit for peptide synthesis. | [reaction suitability]
reaction type: solution phase peptide synthesis | [Synthesis]
Thionyl chloride (1.4 eq.) was slowly added dropwise to a methanolic suspension of 6-aminohexanoic acid (1 eq.) at 0 °C while maintaining stirring. The reaction mixture was continued to be stirred overnight at room temperature. Subsequently, the solvent and unreacted thionyl chloride were removed by distillation under reduced pressure to give methyl 6-aminohexanoate hydrochloride. | [References]
[1] Journal of Medicinal Chemistry, 2001, vol. 44, # 26, p. 4737 - 4740
[2] Journal of Medicinal Chemistry, 2015, vol. 58, # 16, p. 6516 - 6532
[3] Journal of Medicinal Chemistry, 2006, vol. 49, # 20, p. 6094 - 6103
[4] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 16, p. 5950 - 5961
[5] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 15, p. 3591 - 3594 |
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