| Identification | Back Directory | [Name]
JQEZ5 | [CAS]
1913252-04-6 | [Synonyms]
JQZ5
JQEZ5
CS-2764
JQ-EZ-05
JQ-EZ-05 (JQEZ5)
JQEZ5;JQE-Z5;JQE Z5
N-[(1,2-Dihydro-6-methyl-2-oxo-4-propyl-3-pyridinyl)methyl]-1-(1-methylethyl)-6-[6-(4-methyl-1-piperazinyl)-3-pyridinyl]-1H-pyrazolo[3,4-b]pyridine-4-carboxamide
1H-Pyrazolo[3,4-b]pyridine-4-carboxamide, N-[(1,2-dihydro-6-methyl-2-oxo-4-propyl-3-pyridinyl)methyl]-1-(1-methylethyl)-6-[6-(4-methyl-1-piperazinyl)-3-pyridinyl]- | [Molecular Formula]
C30H38N8O2 | [MDL Number]
MFCD31619231 | [MOL File]
1913252-04-6.mol | [Molecular Weight]
542.68 |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMSO:17.93(Max Conc. mg/mL);33.03(Max Conc. mM) | [form ]
A crystalline solid | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
JQEZ5, is a novel and potent EZH2 inhibitor. | [in vivo]
JQEZ5 (75 mg/kg; intraperitoneal injection; daily; for 3 weeks) treatment exhibits rapid and pronounced tumor regression over the three week treatment course. And H3K27me3 levels are largely reduced with treatment further confirming the on-target effect of JQEZ5 in mice[1]. | [IC 50]
EZH2 | [storage]
Store at -20°C |
|
| Company Name: |
Cckinase, Inc.
|
| Tel: |
+1 (732)236-3202 |
| Website: |
www.cckinase.com |
|