| Hazard Information | Back Directory | [Uses]
Sisunatovir (RV521) hydrochloride is a potent and orally active respiratory syncytial virus (RSV) inhibitor with IC50 values of 1.4, 1.0 nM for RSV A, RSV B, respectively. Sisunatovir hydrochloride inhibits RSV infection and reduces virus titers in the lungs of mice[1]. | [in vivo]
Sisunatovir hydrochloride (0, 1, 10, 50 mg/kg; p.o.) reduces virus titers in the lungs of mice with RSV A2 infection[1]. | [References]
[1] DeVincenzo J, et al. A Randomized, Placebo-Controlled, Respiratory Syncytial Virus Human Challenge Study of the Antiviral Efficacy, Safety, and Pharmacokinetics of RV521, an Inhibitor of the RSV-F Protein. Antimicrob Agents Chemother. 2020;64(2):e01884-19 DOI:10.1128/AAC.01884-19 |
|
|