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ChemicalBook--->CAS DataBase List--->188860-26-6

188860-26-6

188860-26-6 Structure

188860-26-6 Structure
IdentificationBack Directory
[Name]

DMA
[CAS]

188860-26-6
[Synonyms]

2,5'-Bi-1H-benzimidazole, 2'-(3,4-dimethoxyphenyl)-5-(4-methyl-1-piperazinyl)-
[Molecular Formula]

C27H28N6O2
[MOL File]

188860-26-6.mol
[Molecular Weight]

468.55
Chemical PropertiesBack Directory
[Melting point ]

220 °C
[Boiling point ]

737.3±70.0 °C(Predicted)
[density ]

1.292±0.06 g/cm3(Predicted)
[storage temp. ]

Sealed in dry,2-8°C
[solubility ]

DMSO : ≥ 54 mg/mL (115.25 mM);
[form ]

Powder
[pka]

10.78±0.10(Predicted)
[color ]

Light brown to brown
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P305+P351+P338
Hazard InformationBack Directory
[Uses]

DMA is a fluorescent compound (λex=340 nm, λem=478 nm).
[Biological Activity]

DMA is a fluorescent compound (λex=340 nm, λem=478 nm).
[in vitro]

The newly synthesized bisbenzimidazole derivatives DMA (6c) is evaluated for their cytotoxicity against human tumor cell lines, which are cervix carcinoma cell line (HeLa), breast carcinoma cell line (MCF7) and brain glioma cell line (U87 ) in comparison to Hoechst. In case of MCF7, the IC 50 is observed at 5.3 μM for DMA. The IC 50 determined in the case of HeLa is 3.4 μM for DMA .

[target]

IC50: 3.4 μM (HeLa cell), 5.3 μM (MCF7 cell)

[References]

[1] Singh M, et al. Synthesis and biological activity of novel inhibitors of topoisomerase I: 2-aryl-substituted 2-bis-1H-benzimidazoles. Eur J Med Chem. 2011 Feb;46(2):659-69. DOI:10.1016/j.ejmech.2010.11.046
Spectrum DetailBack Directory
[Spectrum Detail]

DMA(188860-26-6)1HNMR
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